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Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes
Gao, Hong-Wei; Xie, Chao; Wang, Hai-Ning; Lin, Yu-Jing; Hong, Tian-Pei
关键词nateglinide acarbose free fatty acids asymmetric dimethylarginine
刊名ACTA PHARMACOLOGICA SINICA
2007-04-01
DOI10.1111/j.1745-7254.2007.00534.x
28期:4页:534-539
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE SYNTHASE ; ASYMMETRIC DIMETHYLARGININE CONCENTRATIONS ; INSULIN-RESISTANCE ; ENDOTHELIAL DYSFUNCTION ; GLUCOSE-METABOLISM ; PLASMA-CONCENTRATIONS ; ENDOGENOUS INHIBITOR ; RISK-FACTORS ; FATTY-ACIDS ; SECRETION
英文摘要

Aim: To investigate the acute and chronic effects of nateglinide versus acarbose on plasma asymmetric dimethylarginine (ADMA) levels and lipid profiles in patients with newly-diagnosed type 2 diabetes. Methods: A crossover trial of nateglinide and acarbose was conducted on 16 drug-naive patients with newly-diagnosed type 2 diabetes during a total period of 9 weeks. Plasma glucose, serum insulin, free fatty acids (FFA), lipids and lipoproteins, and plasma ADMA were measured. Results: The efficiencies of a single dose of nateglinide (120 mg) and acarbose (50 mg) for lowering postprandial hyperglycemia were similar. Compared to acarbose, nateglinide significantly increased postprandial insulin release after a standard meal test in patients with type 2 diabetes. Nateglinide acutely decreased postprandial 120 min FFA concentrations and 240 min ADMA levels more significantly than acarbose. The fasting high-density lipoprotein cholesterol level increased and the low-density lipoprotein cholesterol level decreased significantly, but the fasting levels of triglycerides, total cholesterol, and ADMA were unchanged after 4 weeks of treatment with nateglinide. Acarbose did not affect fasting lipid profiles or the ADMA levels after 4 weeks of treatment. Conclusion: These results suggest that the reduction of postprandial FFA and ADMA concentrations induced by nateglinide may be associated with the partial restoration of early-phase insulin secretion and may impart a cardiovascular advantage in comparison with acarbose.

语种英语
WOS记录号WOS:000245224700009
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61996
专题北京大学第三临床医学院_内分泌科
作者单位Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
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GB/T 7714
Gao, Hong-Wei,Xie, Chao,Wang, Hai-Ning,et al. Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes[J]. ACTA PHARMACOLOGICA SINICA,2007,28(4):534-539.
APA Gao, Hong-Wei,Xie, Chao,Wang, Hai-Ning,Lin, Yu-Jing,&Hong, Tian-Pei.(2007).Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes.ACTA PHARMACOLOGICA SINICA,28(4),534-539.
MLA Gao, Hong-Wei,et al."Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes".ACTA PHARMACOLOGICA SINICA 28.4(2007):534-539.
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