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学科主题: 临床医学
题名:
Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion
作者: Xu, Hongliang1; Wang, Zhaoxia1; Zheng, Lemin2,3,4; Zhang, Wei1; Lv, He1; Jin, Suqin1; Yuan, Yun1
刊名: JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2014-11-01
DOI: 10.1136/jclinpath-2013-202069
卷: 67, 期:11, 页:999-1005
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: CHRONIC HEPATITIS-B ; CULTURED HUMAN-CELLS ; LONG-TERM ; DYNAMICS ; TOXICITY ; THERAPY ; COMPLEMENTATION ; CYTOTOXICITY ; TELBIVUDINE ; ZIDOVUDINE
英文摘要:

Aims Myopathy or neuropathy has been associated with lamivudine/telbivudine therapy in hepatitis B patients. We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.

Methods We retrospectively recruited six patients who were diagnosed with nucleotide analogues-associated myopathy or neuropathy. Muscle and nerve biopsy were performed, and the specimens were prepared for the light microscopy and electron microscopy. Genomic DNA was extracted from frozen muscle specimens, and the mitochondrial DNA (mtDNA) content was quantified by real-time PCR.

Results Recovery of the myopathy can be achieved after the discontinuation or changing the drugs to entecavir. Muscle and nerve biopsy revealed similar changes under either the light or electronic microscopy in all the subjects. Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.

Conclusions MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy. Myopathy was characterised by mitochondrial dysfunction accompanied with neurogenic damage due to axonal neuropathy. Ultrastructure changes of mitochondria included vacuolisation, simplification of the cristae and homogenised matrix.

语种: 英语
所属项目编号: 30870864 ; 2011ZX09307-001-07
项目资助者: National Natural Science Foundation of China ; Twelfth Five Years Plan
WOS记录号: WOS:000344067700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62001
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Syst Biomed,Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Hongliang,Wang, Zhaoxia,Zheng, Lemin,et al. Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion[J]. JOURNAL OF CLINICAL PATHOLOGY,2014,67(11):999-1005.
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