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Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion
Xu, Hongliang1; Wang, Zhaoxia1; Zheng, Lemin2,3,4; Zhang, Wei1; Lv, He1; Jin, Suqin1; Yuan, Yun1
刊名JOURNAL OF CLINICAL PATHOLOGY
2014-11-01
DOI10.1136/jclinpath-2013-202069
67期:11页:999-1005
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]CHRONIC HEPATITIS-B ; CULTURED HUMAN-CELLS ; LONG-TERM ; DYNAMICS ; TOXICITY ; THERAPY ; COMPLEMENTATION ; CYTOTOXICITY ; TELBIVUDINE ; ZIDOVUDINE
英文摘要

Aims Myopathy or neuropathy has been associated with lamivudine/telbivudine therapy in hepatitis B patients. We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy.

Methods We retrospectively recruited six patients who were diagnosed with nucleotide analogues-associated myopathy or neuropathy. Muscle and nerve biopsy were performed, and the specimens were prepared for the light microscopy and electron microscopy. Genomic DNA was extracted from frozen muscle specimens, and the mitochondrial DNA (mtDNA) content was quantified by real-time PCR.

Results Recovery of the myopathy can be achieved after the discontinuation or changing the drugs to entecavir. Muscle and nerve biopsy revealed similar changes under either the light or electronic microscopy in all the subjects. Quantitative real-time PCR revealed decrease of mtDNA content in the affected muscle.

Conclusions MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy. Myopathy was characterised by mitochondrial dysfunction accompanied with neurogenic damage due to axonal neuropathy. Ultrastructure changes of mitochondria included vacuolisation, simplification of the cristae and homogenised matrix.

语种英语
WOS记录号WOS:000344067700012
项目编号30870864 ; 2011ZX09307-001-07
资助机构National Natural Science Foundation of China ; Twelfth Five Years Plan
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62001
专题北京大学第一临床医学院_神经内科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Syst Biomed,Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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Xu, Hongliang,Wang, Zhaoxia,Zheng, Lemin,et al. Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion[J]. JOURNAL OF CLINICAL PATHOLOGY,2014,67(11):999-1005.
APA Xu, Hongliang.,Wang, Zhaoxia.,Zheng, Lemin.,Zhang, Wei.,Lv, He.,...&Yuan, Yun.(2014).Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.JOURNAL OF CLINICAL PATHOLOGY,67(11),999-1005.
MLA Xu, Hongliang,et al."Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion".JOURNAL OF CLINICAL PATHOLOGY 67.11(2014):999-1005.
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