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学科主题: 药学
题名:
Diminished serum repetin levels in patients with schizophrenia and bipolar disorder
作者: Wang, Shuai1; Ren, Huixun2; Xu, Jie1; Yu, Yanjun3; Han, Shuiping4; Qiao, Hui5; Cheng, Shaoli6; Xu, Chang5; An, Shucheng5; Ju, Bomiao1; Yu, Chengyuan1; Wang, Chanyuan1; Wang, Tao1; Yang, Zhenjun7; Taylor, Ethan Will8; Zhao, Lijun1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-01-23
DOI: 10.1038/srep07977
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHOROID-PLEXUS CALCIFICATION ; CALCIUM-BINDING-PROTEIN ; DORSOLATERAL PREFRONTAL CORTEX ; WIDE ASSOCIATION ANALYSIS ; LOCUS-CERULEUS ; PSYCHIATRIC-DISORDERS ; BARRIER FUNCTION ; GENE-EXPRESSION ; INCREASED S100B ; HIPPOCAMPUS
英文摘要:

Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human brain, with relatively high levels in choroid plexus, hippocampus and prefrontal cortex. To investigate the expression of RPTN in neuropsychiatric disorders, we determined serum levels of RPTN in patients with schizophrenia (n = 88) or bipolar disorder (n = 34) and in chronic psychostimulant users (n = 91). We also studied its expression in a mouse model of chronic unpredictable mild stress (CUMS). The results showed that serum RPTN levels were significantly diminished in patients with schizophrenia and bipolar disorder or in psychostimulant users, compared with healthy subjects (n = 115) or age-matched controls (n = 92) (p < 0.0001). In CUMS mice, RPTN expression in hippocampus and prefrontal cortex was reduced with progression of the CUMS procedure; the serum RPTN level remained unchanged. Since CUMS is a model for depression and methamphetamine (METH) abuse induced psychosis recapitulates many of the psychotic symptoms of schizophrenia, the results from this study may imply that RPTN plays a potential role in emotional and cognitive processing; its decrease in serum may indicate its involvement in the pathogenesis of schizophrenia and bipolar disorder.

语种: 英语
所属项目编号: 31170855 ; 81272257 ; 2012CB720604
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973)
WOS记录号: WOS:000348287300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62003
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shaanxi Normal Univ, Coll Life Sci, Key Lab Minist Educ Med Plant Resource & Nat Phar, Xian 710062, Peoples R China
2.Xi An Jiao Tong Univ, Sch Med, Dept Pathogen Biol & Immunol, Xian 710061, Peoples R China
3.Xian Mental Hlth Ctr, Dept Clin Chem, Xian 710061, Peoples R China
4.Xi An Jiao Tong Univ, Sch Med, Dept Pathol, Xian 710061, Peoples R China
5.Shaanxi Normal Univ, Coll Life Sci, Xian 710062, Peoples R China
6.Xi An Jiao Tong Univ, Sch Med, Ctr Expt Morphol, Xian 710061, Peoples R China
7.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
8.Univ N Carolina, Joint Sch Nanosci & Nanoengn, Dept Nanosci, Greensboro, NC 27401 USA

Recommended Citation:
Wang, Shuai,Ren, Huixun,Xu, Jie,et al. Diminished serum repetin levels in patients with schizophrenia and bipolar disorder[J]. SCIENTIFIC REPORTS,2015,5.
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