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学科主题: 精神卫生
题名:
Interhemispheric Functional Connectivity and Its Relationships with Clinical Characteristics in Major Depressive Disorder: A Resting State fMRI Study
作者: Wang, Li1,2; Li, Ke3; Zhang, Qing-E4; Zeng, Ya-Wei3; Jin, Zhen3; Dai, Wen-Ji1,2; Su, Yun-Ai1,2; Wang, Gang4; Tan, Yun-Long5; Yu, Xin1,2; Si, Tian-Mei1,2
刊名: PLOS ONE
发表日期: 2013-03-29
DOI: 10.1371/journal.pone.0060191
卷: 8, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DEFAULT MODE NETWORK ; CORPUS-CALLOSUM ; PREFRONTAL CORTEX ; COGNITIVE CONTROL ; TREATMENT-RESISTANT ; EMOTIONAL FACES ; NEURAL ACTIVITY ; WHOLE-BRAIN ; FLUCTUATIONS ; ARCHITECTURE
英文摘要:

Background: Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported inpatients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC)′′.

Methodology/Principal Findings: We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus.

Conclusions/Significance: These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology.

语种: 英语
所属项目编号: 2009-2026
项目资助者: Capital Foundation of Medicine Research and Development
WOS记录号: WOS:000317263900062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62005
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.306 Hosp Peoples Liberat Army, Dept Radiol, Beijing, Peoples R China
4.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China

Recommended Citation:
Wang, Li,Li, Ke,Zhang, Qing-E,et al. Interhemispheric Functional Connectivity and Its Relationships with Clinical Characteristics in Major Depressive Disorder: A Resting State fMRI Study[J]. PLOS ONE,2013,8(3).
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