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学科主题: 临床医学
题名:
Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation
作者: Yan, Chen-Hua; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Liu, Yan-Rong; Chen, Huan; Han, Wei; Wang, Yu; Qin, Ya-Zhen; Huang, Xiao-Jun
刊名: BLOOD
发表日期: 2012-04-05
DOI: 10.1182/blood-2011-09-380386
卷: 119, 期:14, 页:3256-3262
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: ACUTE MYELOID-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; BONE-MARROW-TRANSPLANTATION ; MINIMAL RESIDUAL DISEASE ; MYELODYSPLASTIC SYNDROMES ; EUROPEAN GROUP ; BLOOD ; THERAPY ; HYPORESPONSIVENESS ; QUANTIFICATION
英文摘要:

We studied the impact of risk stratification-directed interventions for minimal residual disease (MRD) on relapse and disease-free survival (DFS) prospectively in 814 subjects with standard-risk acute leukemia receiving allotransplantation in first or second complete remission. A total of 709 subjects were MRD- after transplantation (Group A); 105 subjects were MRD-, 49 received low-dose IL-2 (Group B), and 56 received modified donor lymphocyte infusion (DLI) with or without low-dose IL-2 (Group C). Posttransplantation immune suppression for GVHD was also modified based on MRD state. The cumulative risk of relapse was significantly less and DFS was significantly better in subjects in Group C than in subjects in Group B (P = .001 and P = .002, respectively), but was not different from subjects in Group A (P = .269 and P = .688, respectively). Multivariate analyses confirmed that MRD state and modified DLI were significantly correlated with relapse (P = .000, odds ratio [OR] = 0.255 and P = .000, OR = 0.269) and DFS (P = .001, OR = 0.511 and P = .006, OR = 0.436, respectively). These data suggest that risk stratification-directed interventions with modified DLI in patients with standard-risk acute leukemia who are MRD- after transplantation may improve transplantation outcomes. (Blood. 2012; 119(14): 3256-3262)

语种: 英语
所属项目编号: 30971292 ; 2010-2014 ; 2010-2012
项目资助者: National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty
WOS记录号: WOS:000302773200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62008
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Yan, Chen-Hua,Liu, Dai-Hong,Liu, Kai-Yan,et al. Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation[J]. BLOOD,2012,119(14):3256-3262.
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