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Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation
Yan, Chen-Hua; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Liu, Yan-Rong; Chen, Huan; Han, Wei; Wang, Yu; Qin, Ya-Zhen; Huang, Xiao-Jun
刊名BLOOD
2012-04-05
DOI10.1182/blood-2011-09-380386
119期:14页:3256-3262
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
资助者National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty ; National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty
研究领域[WOS]Hematology
关键词[WOS]ACUTE MYELOID-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; BONE-MARROW-TRANSPLANTATION ; MINIMAL RESIDUAL DISEASE ; MYELODYSPLASTIC SYNDROMES ; EUROPEAN GROUP ; BLOOD ; THERAPY ; HYPORESPONSIVENESS ; QUANTIFICATION
英文摘要

We studied the impact of risk stratification-directed interventions for minimal residual disease (MRD) on relapse and disease-free survival (DFS) prospectively in 814 subjects with standard-risk acute leukemia receiving allotransplantation in first or second complete remission. A total of 709 subjects were MRD- after transplantation (Group A); 105 subjects were MRD-, 49 received low-dose IL-2 (Group B), and 56 received modified donor lymphocyte infusion (DLI) with or without low-dose IL-2 (Group C). Posttransplantation immune suppression for GVHD was also modified based on MRD state. The cumulative risk of relapse was significantly less and DFS was significantly better in subjects in Group C than in subjects in Group B (P = .001 and P = .002, respectively), but was not different from subjects in Group A (P = .269 and P = .688, respectively). Multivariate analyses confirmed that MRD state and modified DLI were significantly correlated with relapse (P = .000, odds ratio [OR] = 0.255 and P = .000, OR = 0.269) and DFS (P = .001, OR = 0.511 and P = .006, OR = 0.436, respectively). These data suggest that risk stratification-directed interventions with modified DLI in patients with standard-risk acute leukemia who are MRD- after transplantation may improve transplantation outcomes. (Blood. 2012; 119(14): 3256-3262)

语种英语
所属项目编号30971292 ; 2010-2014 ; 2010-2012
资助者National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty ; National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty
WOS记录号WOS:000302773200015
引用统计
被引频次:116[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62008
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Yan, Chen-Hua,Liu, Dai-Hong,Liu, Kai-Yan,et al. Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation[J]. BLOOD,2012,119(14):3256-3262.
APA Yan, Chen-Hua.,Liu, Dai-Hong.,Liu, Kai-Yan.,Xu, Lan-Ping.,Liu, Yan-Rong.,...&Huang, Xiao-Jun.(2012).Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation.BLOOD,119(14),3256-3262.
MLA Yan, Chen-Hua,et al."Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation".BLOOD 119.14(2012):3256-3262.
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