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学科主题: 临床医学
题名:
A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice
作者: Deng, Kai1; Zhou, Li Ya1; Lin, San Ren1; Li, Yuan1; Chen, Mo1; Geng, Qiu Ming2; Li, Yu Wen1
关键词: early detection of cancer ; fluorescence ; gastric juice ; spectrometry ; stomach neoplasms
刊名: JOURNAL OF DIGESTIVE DISEASES
发表日期: 2013-06-01
DOI: 10.1111/1751-2980.12040
卷: 14, 期:6, 页:299-304
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ENDOGASTRIC CAPSULE ; DIAGNOSTIC-TOOL ; TRYPTOPHAN ; EXPERIENCE ; SURVIVAL ; MARKER
英文摘要:

Objective This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. Methods Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were divided into three groups: the normal mucosa or chronic non-atrophic gastritis (NM-CNAG) group (n=35), advanced gastric cancer (AGC) group (n=33) and EGC group (n=33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (P1FI) was measured. Results The mean fluorescence intensity of P1FI of gastric juice in AGC (92.1 +/- 10.7) and EGC (90.8 +/- 12.0) groups was significantly higher than that in the NM-CNAG group (55.7 +/- 7.5) (AGCvsNM-CNAG, P=0.006 and EGCvsNM-CNAG, P=0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [CI] 0.5530.810, P=0.010) and 0.655 (95% CI 0.5220.787, P=0.028). With the P1FI of 47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively. Conclusions The enhancement of P1FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.

语种: 英语
所属项目编号: 30973415
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000318234500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62012
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ Third Hosp, Med Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Deng, Kai,Zhou, Li Ya,Lin, San Ren,et al. A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice[J]. JOURNAL OF DIGESTIVE DISEASES,2013,14(6):299-304.
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