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Biological Fractionation of Lead Isotopes in Sprague-Dawley Rats Lead Poisoned via the Respiratory Tract
Wu, Jing1,3; Liu, Duojian1; Xie, Qing1,2; Wang, Jingyu1,2
刊名PLOS ONE
2012-12-26
DOI10.1371/journal.pone.0052462
7期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EXPOSURE ; CHILDREN ; THRESHOLD ; TOXICITY ; RATIOS ; BLOOD ; REDUCTION ; POLLUTION ; CADMIUM ; ZINC
英文摘要

Objectives: It was considered that lead isotope ratios did not change during physical, chemical, or biological processes. Thus, lead isotope ratios have been used as fingerprints to identify possible lead sources. However, recent evidence has shown that the lead isotope ratios among different biological samples in human are not always identical from its lead origins in vitro. An animal experiment was conducted to explore the biological fractionation of lead isotopes in biological systems.

Methods: 24 male Sprague-Dawley (SD) rats were divided into groups that received acute lead exposure (0, 0.02, 0.2, or 2 mg/kg body weight of lead acetate) via the respiratory route every day for 5 days. Biological samples (i.e., blood, urine, and feces) were collected for comparison with the lead acetate (test substance) and the low-lead animal feed (diet) administered to the rats. The lead isotope ratios were determined by inductively coupled plasma mass spectrometry (ICP-MS).

Results: There are significant differences (p<0.05) in lead isotope ratios between blood, urine, and feces. Moreover, a nonlinear relationship between the blood lead concentration and the blood lead isotope ratios was observed. There is also a threshold effect to the fractionation function. Only the blood isotope ratio of Pb-204/Pb-206 matches the test substance well. As for feces, when Pb-204/Pb-206 ratio is considered, there is no significant difference between feces-test substance pairs in medium and high dose group.

Conclusions: The biological fractionation of lead isotopes in SD rats was observed. Moreover, there might be a threshold for the biological fractionation of lead isotopes which is depending on whole blood lead level. It is considered to be more reliable that we compared the isotope ratios of potential lead hazards with both blood and feces lead fingerprints especially for Pb-204/Pb-206 ratio under high-dose exposure.

语种英语
WOS记录号WOS:000313618800092
项目编号30972434
资助机构Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62015
专题北京大学公共卫生学院
北京大学第三临床医学院_介入血管外科
北京大学临床肿瘤学院_核医学科
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China
3.Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Wu, Jing,Liu, Duojian,Xie, Qing,et al. Biological Fractionation of Lead Isotopes in Sprague-Dawley Rats Lead Poisoned via the Respiratory Tract[J]. PLOS ONE,2012,7(12).
APA Wu, Jing,Liu, Duojian,Xie, Qing,&Wang, Jingyu.(2012).Biological Fractionation of Lead Isotopes in Sprague-Dawley Rats Lead Poisoned via the Respiratory Tract.PLOS ONE,7(12).
MLA Wu, Jing,et al."Biological Fractionation of Lead Isotopes in Sprague-Dawley Rats Lead Poisoned via the Respiratory Tract".PLOS ONE 7.12(2012).
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