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学科主题: 临床医学
题名:
Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart
作者: Gong, Kai-zheng; Zhang, Hui; Du, Jian-hai; Zhang, You-yi
关键词: receptors ; adrenergic ; signal transduction ; STAT3 transcription factor ; heart
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2007-02-01
DOI: 10.1111/j.1745-7254.2007.00525.x
卷: 28, 期:2, 页:153-165
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-COUPLED RECEPTORS ; SRC TYROSINE KINASE ; BETA-ADRENERGIC-RECEPTORS ; GROWTH-FACTOR RECEPTORS ; SMOOTH-MUSCLE-CELLS ; JAK-STAT ; DEPENDENT MECHANISM ; PHOSPHOLIPASE-C ; ALPHA(1)-ADRENERGIC RECEPTORS ; BETA-2-ADRENERGIC RECEPTOR
英文摘要:

Recently, there have been important advancements in our understanding of the signaling mechanisms of adrenoreceptors (AR) and signal transducers and activators of transcription 3 (STAT3). While their crucial roles in the pathological processes of the heart are well established, accumulating evidence suggests there is a complex pattern of crosstalk between these 2 signaling pathways. Moreover, the potential for crosstalk occurs at multiple levels in each signaling cascade and involves receptor transactivation, G proteins, small GTPases, cyclic adenosine 3′, 5′-monophosphate/protein kinase A, protein kinase C, scaffold/adaptor proteins, protein tyrosine kinases, and mitogen-activated protein kinases. In addition, post-translational modification (eg acetylation) of STAT3 may provide a link between STAT3 and AR signaling. In particular, crosstalk between these 2 systems in the heart would appear to be dependent upon the species/tissue studied, developmental stage, and eliciting stimulus. This at least partly accounts for the epigenetic effects on biological function that is mediated by the 2 signaling pathways. Elucidation of these mechanisms will provide new targets in the development of novel clinical strategies for heart disorders.

语种: 英语
WOS记录号: WOS:000243697900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62016
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Gong, Kai-zheng,Zhang, Hui,Du, Jian-hai,et al. Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart[J]. ACTA PHARMACOLOGICA SINICA,2007,28(2):153-165.
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