北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart
作者: Gong, Kai-zheng; Zhang, Hui; Du, Jian-hai; Zhang, You-yi
关键词: receptors ; adrenergic ; signal transduction ; STAT3 transcription factor ; heart
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2007-02-01
DOI: 10.1111/j.1745-7254.2007.00525.x
卷: 28, 期:2, 页:153-165
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-COUPLED RECEPTORS ; SRC TYROSINE KINASE ; BETA-ADRENERGIC-RECEPTORS ; GROWTH-FACTOR RECEPTORS ; SMOOTH-MUSCLE-CELLS ; JAK-STAT ; DEPENDENT MECHANISM ; PHOSPHOLIPASE-C ; ALPHA(1)-ADRENERGIC RECEPTORS ; BETA-2-ADRENERGIC RECEPTOR
英文摘要:

Recently, there have been important advancements in our understanding of the signaling mechanisms of adrenoreceptors (AR) and signal transducers and activators of transcription 3 (STAT3). While their crucial roles in the pathological processes of the heart are well established, accumulating evidence suggests there is a complex pattern of crosstalk between these 2 signaling pathways. Moreover, the potential for crosstalk occurs at multiple levels in each signaling cascade and involves receptor transactivation, G proteins, small GTPases, cyclic adenosine 3′, 5′-monophosphate/protein kinase A, protein kinase C, scaffold/adaptor proteins, protein tyrosine kinases, and mitogen-activated protein kinases. In addition, post-translational modification (eg acetylation) of STAT3 may provide a link between STAT3 and AR signaling. In particular, crosstalk between these 2 systems in the heart would appear to be dependent upon the species/tissue studied, developmental stage, and eliciting stimulus. This at least partly accounts for the epigenetic effects on biological function that is mediated by the 2 signaling pathways. Elucidation of these mechanisms will provide new targets in the development of novel clinical strategies for heart disorders.

语种: 英语
WOS记录号: WOS:000243697900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62016
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Gong, Kai-zheng,Zhang, Hui,Du, Jian-hai,et al. Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart[J]. ACTA PHARMACOLOGICA SINICA,2007,28(2):153-165.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gong, Kai-zheng]'s Articles
[Zhang, Hui]'s Articles
[Du, Jian-hai]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gong, Kai-zheng]‘s Articles
[Zhang, Hui]‘s Articles
[Du, Jian-hai]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace