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学科主题基础医学
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
Liu, Bo1,2,3; Liu, Yuan-Feng1,2; Du, Ya-Rui3; Mardaryev, Andrei N.5; Yang, Wei4; Chen, Hui3; Xu, Zhi-Mei3; Xu, Chen-Qi4; Zhang, Xiao-Ren6,7; Botchkarev, Vladimir A.5,8; Zhang, Yu1,2; Xu, Guo-Liang3
关键词Thymic epithelial cell Cbx4 Thymic hypoplasia T-lymphopoiesis p63 (Trp63) Polycomb Epithelial progenitor
刊名DEVELOPMENT
2013-02-15
DOI10.1242/dev.085035
140期:4页:780-788
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology
研究领域[WOS]Developmental Biology
关键词[WOS]STEM-CELLS ; STRATIFIED EPITHELIA ; PROTEINS ; DIFFERENTIATION ; EXPRESSION ; ORGANOGENESIS ; PROGENITORS ; MECHANISMS ; BMI-1 ; MICE
英文摘要

Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific deletion of Cbx4 shows that the compromised thymopoiesis is rooted in a defective epithelial compartment. Cbx4-deficient TECs exhibit impaired proliferative capacity, and the limited thymic epithelial architecture quickly deteriorates in postnatal mutant mice, leading to an almost complete blockade of T-cell development shortly after birth and markedly reduced peripheral T-cell populations in adult mice. Furthermore, we show that Cbx4 physically interacts and functionally correlates with p63, which is a transcriptional regulator that is proposed to be important for the maintenance of the stemness of epithelial progenitors. Together, these data establish Cbx4 as a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.

语种英语
WOS记录号WOS:000314405000009
项目编号2011CB946100 ; 90919061 ; 81261130314 ; 30830091 ; AR049778
资助机构Ministry of Science and Technology of China ; National Science Foundation of China ; National Institutes of Health (USA)
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62022
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
3.Chinese Acad Sci, State Key Lab Mol Biol, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Mol Cell Biol, Shanghai 200031, Peoples R China
5.Univ Bradford, Ctr Skin Sci, Bradford BD7 1DP, W Yorkshire, England
6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
8.Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA
推荐引用方式
GB/T 7714
Liu, Bo,Liu, Yuan-Feng,Du, Ya-Rui,et al. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function[J]. DEVELOPMENT,2013,140(4):780-788.
APA Liu, Bo.,Liu, Yuan-Feng.,Du, Ya-Rui.,Mardaryev, Andrei N..,Yang, Wei.,...&Xu, Guo-Liang.(2013).Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.DEVELOPMENT,140(4),780-788.
MLA Liu, Bo,et al."Cbx4 regulates the proliferation of thymic epithelial cells and thymus function".DEVELOPMENT 140.4(2013):780-788.
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