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Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia
Liang, Ying1,2; Su, Yun-Ai1,2; Zhao, Zhen-Guo1,2; Gao, Nan1,2; Huang, Ji-Zhong3; Tang, Mao-Qin4; Li, Ke-Qing5; Yang, Fu-De6; Yu, Xin1,2; Si, Tian-Mei1,2
关键词antipsychotics schizophrenia hyperprolactinemia bone metabolism
刊名JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2015-10-01
DOI10.1097/JCP.0000000000000379
35期:5页:583-586
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]MINERAL DENSITY ; PROLACTIN LEVELS ; OSTEOPOROSIS ; ANTIPSYCHOTICS ; MEDICATION ; WOMEN ; MASS ; RISK
英文摘要

Objective This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs.

Methods Patients included in the study were randomly assigned to receive haloperidol, amisulpride, or quetiapine monotherapy in an open-label manner. Serum osteocalcin (OC, a marker of bone formation), C-terminal peptide of type I collagen (CTX, a marker of bone resorption), prolactin (PRL), estradiol, and testosterone were measured in 70 patients at baseline and after 4 weeks of antipsychotic treatment.

Results A repeated-measures analysis of variance revealed a significant difference in CTX levels and in the OC to CTX ratio between treatment groups (F = 4.481, P < 0.05; F = 8.114, P < 0.01). After 4 weeks of treatment, only the amisulpride group had significantly increased CTX levels and decreased OC/CTX. In addition, an obvious increase in PRL level and a reduction of sex hormone secretion after amisulpride treatment were found. No significant changes in bone turnover were observed in the haloperidol or quetiapine groups. Notably, a positive correlation between the CTX change to the change in PRL after treatment (r = 0.255, P < 0.05) was observed.

Conclusions The PRL-raising antipsychotic drug amisulpride influenced bone turnover balance very early in the course of treatment, which may require long-term monitoring of bone metabolism. Bone resorption marker changes induced by acute antipsychotic drug treatment are likely related to increased PRL levels.

语种英语
WOS记录号WOS:000361036100014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62026
专题北京大学精神卫生研究所
作者单位1.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
2.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
3.Shandong Mental Hlth Ctr, Jinan, Peoples R China
4.Hebei Mental Hlth Ctr, Baoding, Peoples R China
5.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100871, Peoples R China
6.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
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GB/T 7714
Liang, Ying,Su, Yun-Ai,Zhao, Zhen-Guo,et al. Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2015,35(5):583-586.
APA Liang, Ying.,Su, Yun-Ai.,Zhao, Zhen-Guo.,Gao, Nan.,Huang, Ji-Zhong.,...&Si, Tian-Mei.(2015).Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,35(5),583-586.
MLA Liang, Ying,et al."Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 35.5(2015):583-586.
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