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Proteome analysis of the sera from Chinese Parkinson′s disease patients
Zhao, Xin1,2; Xiao, Wei-Zhong3; Pu, Xiao-Ping1,2; Zhong, Li-Jun4
关键词2-DE Parkinson&prime s disease Biomarker Proteomics Serum
刊名NEUROSCIENCE LETTERS
2010-07-26
DOI10.1016/j.neulet.2010.05.063
479期:2页:175-179
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]POSITIVE CORRELATION ; GEL-ELECTROPHORESIS ; CEREBROSPINAL-FLUID ; CLINICAL-DIAGNOSIS ; URINARY LEVELS ; ULINASTATIN ; ALPHA-1-MICROGLOBULIN ; IDENTIFICATION ; ACCURACY ; MICE
英文摘要

Clinical proteomics is a powerful tool that can be used to identify proteins that are differentially expressed in disease states, leading to greater understanding of the molecular and cellular events that contribute to disease. The aim of this study was to identify protein changes in the sera from Chinese Parkinson′s disease (PD) patients, with the goal of finding biomarkers for PD diagnosis, and to elucidate the events occurring at the onset of PD. Using differential display to identify proteins with altered expression in PD patients, we obtained 15 protein spots corresponding to 13 different gene products that were likely to be involved in PD. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins, 7 of which have never previously been associated with PD patients. They are likely to be involved in antioxidation, lipid metabolism, intracellular transport, cell proliferation and immunoregulation. The altered levels of these proteins may be related to the pathophysiological mechanisms of PD. As a result, some of these proteins could be considered as candidate biomarkers. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000280904500020
项目编号2004CB518902
资助机构National Program on Key Basic Research
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62030
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
北京大学医药卫生分析中心_研发办公室
作者单位1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Peking Univ, Med & Pharmaceut Anal Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xin,Xiao, Wei-Zhong,Pu, Xiao-Ping,et al. Proteome analysis of the sera from Chinese Parkinson′s disease patients[J]. NEUROSCIENCE LETTERS,2010,479(2):175-179.
APA Zhao, Xin,Xiao, Wei-Zhong,Pu, Xiao-Ping,&Zhong, Li-Jun.(2010).Proteome analysis of the sera from Chinese Parkinson′s disease patients.NEUROSCIENCE LETTERS,479(2),175-179.
MLA Zhao, Xin,et al."Proteome analysis of the sera from Chinese Parkinson′s disease patients".NEUROSCIENCE LETTERS 479.2(2010):175-179.
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