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学科主题: 药学
题名:
Proteome analysis of the sera from Chinese Parkinson′s disease patients
作者: Zhao, Xin1,2; Xiao, Wei-Zhong3; Pu, Xiao-Ping1,2; Zhong, Li-Jun4
关键词: 2-DE ; Parkinson&prime ; s disease ; Biomarker ; Proteomics ; Serum
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-07-26
DOI: 10.1016/j.neulet.2010.05.063
卷: 479, 期:2, 页:175-179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: POSITIVE CORRELATION ; GEL-ELECTROPHORESIS ; CEREBROSPINAL-FLUID ; CLINICAL-DIAGNOSIS ; URINARY LEVELS ; ULINASTATIN ; ALPHA-1-MICROGLOBULIN ; IDENTIFICATION ; ACCURACY ; MICE
英文摘要:

Clinical proteomics is a powerful tool that can be used to identify proteins that are differentially expressed in disease states, leading to greater understanding of the molecular and cellular events that contribute to disease. The aim of this study was to identify protein changes in the sera from Chinese Parkinson′s disease (PD) patients, with the goal of finding biomarkers for PD diagnosis, and to elucidate the events occurring at the onset of PD. Using differential display to identify proteins with altered expression in PD patients, we obtained 15 protein spots corresponding to 13 different gene products that were likely to be involved in PD. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins, 7 of which have never previously been associated with PD patients. They are likely to be involved in antioxidation, lipid metabolism, intracellular transport, cell proliferation and immunoregulation. The altered levels of these proteins may be related to the pathophysiological mechanisms of PD. As a result, some of these proteins could be considered as candidate biomarkers. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: National Program on Key Basic Research
WOS记录号: WOS:000280904500020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62030
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Peking Univ, Med & Pharmaceut Anal Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Xin,Xiao, Wei-Zhong,Pu, Xiao-Ping,et al. Proteome analysis of the sera from Chinese Parkinson′s disease patients[J]. NEUROSCIENCE LETTERS,2010,479(2):175-179.
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