IR@PKUHSC  > 北京大学药学院
学科主题药学
Synthesis and antitumor activities of glucan derivatives
Du, YG; Gu, GF; Hua, YX; Wei, GH; Ye, XS; Yu, GL
关键词carbohydrates glycosylations antitumor agents glycodendrimers oligosaccharides
刊名TETRAHEDRON
2004-07-19
DOI10.1016/j.tet.2004.05.086
60期:30页:6345-6351
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ANTI-TUMOR POLYSACCHARIDE ; SELECTIN INHIBITORS ; CHEMICAL-STRUCTURE ; HIGHLY EFFICIENT ; REPEATING UNIT ; GLYCOSIDES ; GLYCANS ; OLIGOSACCHARIDES ; AGGLUTINATION ; SCHIZOPHYLLAN
英文摘要

A highly efficient and practical method for the preparation of beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-beta-D-Glc-(1-->6)-beta-D-Glc-(1-->6)-[beta-D-Glc-(1-->3)]-D-Glc-OMe was described. A dendritic nonasaccharide was also synthesized. The antitumor activities of hexasaccharide, the dendrimer, their sulfated derivatives, together with the natural glucan-protein and the corresponding polysaccharide isolated from barmy mycelium of Grifola frondosa, were preliminarily investigated based on Sarcoma-180 studies in mice tests. Our results suggest that the sulfated branching oligosaccharide and natural glycoprotein have better antitumor activities comparing to the parent sugar residue (oligosaccharide or polysaccharide). (C) 2004 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000222712400009
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62037
专题北京大学药学院
作者单位1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China
3.Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China
推荐引用方式
GB/T 7714
Du, YG,Gu, GF,Hua, YX,et al. Synthesis and antitumor activities of glucan derivatives[J]. TETRAHEDRON,2004,60(30):6345-6351.
APA Du, YG,Gu, GF,Hua, YX,Wei, GH,Ye, XS,&Yu, GL.(2004).Synthesis and antitumor activities of glucan derivatives.TETRAHEDRON,60(30),6345-6351.
MLA Du, YG,et al."Synthesis and antitumor activities of glucan derivatives".TETRAHEDRON 60.30(2004):6345-6351.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Du, YG]的文章
[Gu, GF]的文章
[Hua, YX]的文章
百度学术
百度学术中相似的文章
[Du, YG]的文章
[Gu, GF]的文章
[Hua, YX]的文章
必应学术
必应学术中相似的文章
[Du, YG]的文章
[Gu, GF]的文章
[Hua, YX]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。