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学科主题: 药学
题名:
Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
作者: Jia, Lejiao1; Zhang, Dianrui1; Li, Zhenyu2; Duan, Cunxian1; Wang, Yancai1; Feng, Feifei1; Wang, Feihu1; Liu, Yue1; Zhang, Qiang3
关键词: Silybin ; Nanostructured lipid carriers ; Pharmacokinetics ; Tissue distribution ; In vitro release
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2010-10-15
DOI: 10.1016/j.colsurfb.2010.06.008
卷: 80, 期:2, 页:213-218
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]: Biophysics ; Chemistry ; Materials Science
关键词[WOS]: MILK THISTLE ; ORAL BIOAVAILABILITY ; BODY DISTRIBUTION ; BINARY-MIXTURES ; LIVER-DISEASE ; SOLID LIPIDS ; NANOPARTICLES ; SILYMARIN ; SYSTEM ; MARIANUM
英文摘要:

The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for the intravenous delivery of silybin, a poorly water-soluble antihepatopathy agent. Silybin-NLC was prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The resultant NLC had a mean size 232.1 nm and a zeta potential of -20.7 mV. The differential scanning calorimetry (DSC) analysis indicated that silybin was not in crystalline state in the NLC. In vitro data for release of the drug from silybin-NLC was fitted to a two-stage exponential kinetic model. The pharmacokinetics and tissue distribution of silybin-NLC were studied after intravenous administration using New Zealand rabbits and Kunming mice as experimental animals. A silybin control solution was studied parallelly. Silybin-NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with silybin solution. The tissue distribution demonstrated a high uptake of silybin-NLC in RES organs particularly in liver. These results indicate that NLC is a potential sustained release and targeting system for silybin. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000281077500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62039
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Coll Pharm, Dept Med Chem, Jinan 250012, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Jia, Lejiao,Zhang, Dianrui,Li, Zhenyu,et al. Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,80(2):213-218.
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