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Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
Jia, Lejiao1; Zhang, Dianrui1; Li, Zhenyu2; Duan, Cunxian1; Wang, Yancai1; Feng, Feifei1; Wang, Feihu1; Liu, Yue1; Zhang, Qiang3
关键词Silybin Nanostructured lipid carriers Pharmacokinetics Tissue distribution In vitro release
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2010-10-15
DOI10.1016/j.colsurfb.2010.06.008
80期:2页:213-218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]MILK THISTLE ; ORAL BIOAVAILABILITY ; BODY DISTRIBUTION ; BINARY-MIXTURES ; LIVER-DISEASE ; SOLID LIPIDS ; NANOPARTICLES ; SILYMARIN ; SYSTEM ; MARIANUM
英文摘要

The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for the intravenous delivery of silybin, a poorly water-soluble antihepatopathy agent. Silybin-NLC was prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The resultant NLC had a mean size 232.1 nm and a zeta potential of -20.7 mV. The differential scanning calorimetry (DSC) analysis indicated that silybin was not in crystalline state in the NLC. In vitro data for release of the drug from silybin-NLC was fitted to a two-stage exponential kinetic model. The pharmacokinetics and tissue distribution of silybin-NLC were studied after intravenous administration using New Zealand rabbits and Kunming mice as experimental animals. A silybin control solution was studied parallelly. Silybin-NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with silybin solution. The tissue distribution demonstrated a high uptake of silybin-NLC in RES organs particularly in liver. These results indicate that NLC is a potential sustained release and targeting system for silybin. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000281077500016
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:75[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62039
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Coll Pharm, Dept Med Chem, Jinan 250012, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jia, Lejiao,Zhang, Dianrui,Li, Zhenyu,et al. Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,80(2):213-218.
APA Jia, Lejiao.,Zhang, Dianrui.,Li, Zhenyu.,Duan, Cunxian.,Wang, Yancai.,...&Zhang, Qiang.(2010).Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies.COLLOIDS AND SURFACES B-BIOINTERFACES,80(2),213-218.
MLA Jia, Lejiao,et al."Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies".COLLOIDS AND SURFACES B-BIOINTERFACES 80.2(2010):213-218.
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