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学科主题基础医学
Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat
Jiang, Yu-Qiu1,2; Xing, Guo-Gang1; Wang, Sheng-Lan4; Tu, Hui-Yin1; Chi, Ye-Nan1,2; Li, Jie1; Liu, Feng-Yu1,2; Han, Ji-Sheng1,2,3; Wan, You1,2,3
关键词Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel I-h Chronic Constriction Injury (Cci) Neuropathic Pain Ectopic Discharge
刊名PAIN
2008-07-31
DOI10.1016/j.pain.2007.10.011
137期:3页:495-506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]DORSAL-ROOT GANGLION ; CHRONIC CONSTRICTION INJURY ; PRIMARY AFFERENT NEURONS ; NEUROPATHIC PAIN ; SCIATIC-NERVE ; SODIUM-CHANNELS ; TACTILE ALLODYNIA ; SENSORY NEURONS ; PACEMAKER CHANNELS ; ECTOPIC DISCHARGES
英文摘要

Peripheral nerve injury causes neuropathic pain including mechanical allodynia and thermal hyperalgesia due to central and peripheral sensitization. Spontaneous ectopic discharges derived from dorsal root ganglion (DRG) neurons and from the sites of injury are a key factor in the initiation of this sensitization. Numerous Studies have focused primarily on DRG neurons; however, the injured axons themselves likely play an equally important role. Previous studies of neuropathic pain rats with spinal nerve ligation (SNL) showed that the hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel in DRG neuronal bodies is important for the development of neuropathic pain. Here, we investigate the role of the axonal HCN channel in neuropathic pain rats. Using the chronic constriction injury (CCI) model, we found abundant axonal accumulation of HCN channel protein at the injured sites accompanied by a slight decrease in DRG neuronal bodies. The function of these accumulated channels was verified by local application of ZD7288, a specific HCN blocker, which significantly suppressed the ectopic discharges from injured nerve fibers with no effect on impulse conduction. Moreover, mechanical allodynia, but not thermal hyperalgesia, was relieved significantly by ZD7288. These results suggest that axonal HCN channel accumulation plays an important role in ectopic discharges from injured spinal nerves and contributes to the development of mechanical allodynia, in neuropathic pain rats. (C) 2007 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000258359500008
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62041
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Peking Univ, Dept Pathol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Yu-Qiu,Xing, Guo-Gang,Wang, Sheng-Lan,et al. Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat[J]. PAIN,2008,137(3):495-506.
APA Jiang, Yu-Qiu.,Xing, Guo-Gang.,Wang, Sheng-Lan.,Tu, Hui-Yin.,Chi, Ye-Nan.,...&Wan, You.(2008).Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat.PAIN,137(3),495-506.
MLA Jiang, Yu-Qiu,et al."Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat".PAIN 137.3(2008):495-506.
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