北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科  > 期刊论文
学科主题: 临床医学
题名:
Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients
作者: Lu, Hai-Ying1; Zhuang, Li-Wei1; Yu, Yan-Yan1; Si, Chong-Wen1; Li, Jun; Zhang, Jian-Jun2; Zeng, Zheng1; Chen, Xin-Yue3; Han, Zhong-Hou4; Chen, Yong5
关键词: covalently closed circular DNA ; hepatitis B virus ; sequential therapy ; lamivudine ; interferon
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2008-02-28
DOI: 10.3748/wjg.14.1268
卷: 14, 期:8, 页:1268-1273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: REAL-TIME PCR ; LAMIVUDINE THERAPY ; ADEFOVIR DIPIVOXIL ; PRECORE MUTATIONS ; INFECTED PATIENTS ; VIRUS GENOTYPES ; CORE PROMOTER ; QUANTITATION ; ENTECAVIR ; CCCDNA
英文摘要:

AIM: To evaluate the effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA (ccc DNA) in HBeAg-positive chronic hepatitis B patients.

METHODS: Seventy-one patients received lamivudine (n = 35), or sequential therapy with lamivudine-interferon alpha 2b (IFN-alpha 2b, n = 24) for 48 wk, or IFN-alpha 2b (n = 12) for 24 wk. All subjects were followed up for 24 wk, Intrahepatic ccc DNA was measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.

RESULTS: Sequential lamivudine-INF-alpha therapy, lamivudine and INF-alpha monotherapy reduced ccc DNA of 1.7 log, 1.4 log and 0.8 log, respectively (P < 0.05). Seventeen out of the 71 patients developed HBeAg seroconversion, the reduction of ccc DNA in the HBeAg seroconversion patients was more significant than that in the HBeAg positive patients (3.0 log vs 1.6 log, P = 0.0407). Twenty-four weeks after antiviral therapy withdrawal, 16 patients had a sustained virological response, the baseline intrahepatic ccc DNA in the patients with a sustained virological response was significantly lower than that in the patients with virological rebound (4.6 log vs 5.4 log, P = 0.0472). HBV genotype C accounted for 85.9% (n = 61), and genotype B for 14.1% (n = 10), respectively, in the 71 patients. There was no significant difference in the change of ccc DNA level between HBV genotypes C and B (2.1 log vs 1.9 log).

CONCLUSION: Forty-eight week sequential lamivudine-INF-alpha therapy and lamivudine monotherapy reduce ccc DNA more significantly than 24-wk INF-alpha monotherapy. Low baseline intrahepatic ccc DNA level may predict the long-term efficacy of antiviral treatment. HBV genotypes C and B have no obvious influence on ccc DNA load. (c) 2008 WJG. All rights reserved.

语种: 英语
WOS记录号: WOS:000253599100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62042
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Beijing Zhongfuyouxin, Beijing 100085, Peoples R China
3.Beijing Youan Hosp, Beijing 100054, Peoples R China
4.Qinhuangdao Third Hosp, Qinhuangdao 066000, Hebei Province, Peoples R China
5.Huaian Infect Dis Hosp, Huaian 223300, Peoples R China

Recommended Citation:
Lu, Hai-Ying,Zhuang, Li-Wei,Yu, Yan-Yan,et al. Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(8):1268-1273.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lu, Hai-Ying]'s Articles
[Zhuang, Li-Wei]'s Articles
[Yu, Yan-Yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lu, Hai-Ying]‘s Articles
[Zhuang, Li-Wei]‘s Articles
[Yu, Yan-Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace