IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients
Lu, Hai-Ying1; Zhuang, Li-Wei1; Yu, Yan-Yan1; Si, Chong-Wen1; Li, Jun; Zhang, Jian-Jun2; Zeng, Zheng1; Chen, Xin-Yue3; Han, Zhong-Hou4; Chen, Yong5
关键词covalently closed circular DNA hepatitis B virus sequential therapy lamivudine interferon
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2008-02-28
DOI10.3748/wjg.14.1268
14期:8页:1268-1273
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]REAL-TIME PCR ; LAMIVUDINE THERAPY ; ADEFOVIR DIPIVOXIL ; PRECORE MUTATIONS ; INFECTED PATIENTS ; VIRUS GENOTYPES ; CORE PROMOTER ; QUANTITATION ; ENTECAVIR ; CCCDNA
英文摘要

AIM: To evaluate the effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA (ccc DNA) in HBeAg-positive chronic hepatitis B patients.

METHODS: Seventy-one patients received lamivudine (n = 35), or sequential therapy with lamivudine-interferon alpha 2b (IFN-alpha 2b, n = 24) for 48 wk, or IFN-alpha 2b (n = 12) for 24 wk. All subjects were followed up for 24 wk, Intrahepatic ccc DNA was measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.

RESULTS: Sequential lamivudine-INF-alpha therapy, lamivudine and INF-alpha monotherapy reduced ccc DNA of 1.7 log, 1.4 log and 0.8 log, respectively (P < 0.05). Seventeen out of the 71 patients developed HBeAg seroconversion, the reduction of ccc DNA in the HBeAg seroconversion patients was more significant than that in the HBeAg positive patients (3.0 log vs 1.6 log, P = 0.0407). Twenty-four weeks after antiviral therapy withdrawal, 16 patients had a sustained virological response, the baseline intrahepatic ccc DNA in the patients with a sustained virological response was significantly lower than that in the patients with virological rebound (4.6 log vs 5.4 log, P = 0.0472). HBV genotype C accounted for 85.9% (n = 61), and genotype B for 14.1% (n = 10), respectively, in the 71 patients. There was no significant difference in the change of ccc DNA level between HBV genotypes C and B (2.1 log vs 1.9 log).

CONCLUSION: Forty-eight week sequential lamivudine-INF-alpha therapy and lamivudine monotherapy reduce ccc DNA more significantly than 24-wk INF-alpha monotherapy. Low baseline intrahepatic ccc DNA level may predict the long-term efficacy of antiviral treatment. HBV genotypes C and B have no obvious influence on ccc DNA load. (c) 2008 WJG. All rights reserved.

语种英语
WOS记录号WOS:000253599100019
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62042
专题北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Beijing Zhongfuyouxin, Beijing 100085, Peoples R China
3.Beijing Youan Hosp, Beijing 100054, Peoples R China
4.Qinhuangdao Third Hosp, Qinhuangdao 066000, Hebei Province, Peoples R China
5.Huaian Infect Dis Hosp, Huaian 223300, Peoples R China
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GB/T 7714
Lu, Hai-Ying,Zhuang, Li-Wei,Yu, Yan-Yan,et al. Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(8):1268-1273.
APA Lu, Hai-Ying.,Zhuang, Li-Wei.,Yu, Yan-Yan.,Si, Chong-Wen.,Li, Jun.,...&Chen, Yong.(2008).Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients.WORLD JOURNAL OF GASTROENTEROLOGY,14(8),1268-1273.
MLA Lu, Hai-Ying,et al."Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients".WORLD JOURNAL OF GASTROENTEROLOGY 14.8(2008):1268-1273.
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