北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
How can we improve antibody-based cancer therapy?
作者: Yan, Li1,2; Ehrlich, Paula J.3; Gibson, Raymond1; Pickett, Cheryl1; Beckman, Robert A.1
关键词: monoclonal antibodies ; solid tumors ; cancer ; pharmacogenomics ; biodistribution ; bioengineering
刊名: MABS
发表日期: 2009
卷: 1, 期:1, 页:67-70
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: METASTATIC BREAST-CANCER ; C-RECEPTOR POLYMORPHISMS ; MONOCLONAL-ANTIBODY ; SOLID TUMORS ; COLORECTAL-CANCER ; CHEMOTHERAPY ; CETUXIMAB ; AFFINITY ; BINDING ; EFFICACY
英文摘要:

Monoclonal antibodies (mAbs) as a class of novel oncology therapeutics are demonstrating clinical efficacy as measured by tumor response (shrinkage in tumor size), and prolongations in progression-free survival (PFS) and overall survival (OS). However, clinical benefits are often limited to when antibodies are used in combination with chemotherapy or radiation modalities, with tumor responses only seen in a fraction of patients, and improvements in PFS and OS are incremental.(1) The potential of mAbs and mAb constructs has yet to be fully exploited for maximal clinical benefit. New approaches to further improve the effectiveness of these mAb therapies include (1) selection of patients who may derive the most benefit based on the molecular characteristics of their tumors; (2) improvements in biodistribution to maximize delivery of mAbs to susceptible tumor cells; and (3) optimization of antibody immune effector mechanisms such as antibody dependent cellular cytotoxicity (ADCC).

语种: 英语
WOS记录号: WOS:000271809200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62043
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Merck Res Labs, N Wales, PA USA
2.Peking Univ, Beijing Canc Res Inst, Beijing Canc Hosp, Beijing 100871, Peoples R China
3.Locus Pharmaceut, Blue Bell, PA USA

Recommended Citation:
Yan, Li,Ehrlich, Paula J.,Gibson, Raymond,et al. How can we improve antibody-based cancer therapy?[J]. MABS,2009,1(1):67-70.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yan, Li]'s Articles
[Ehrlich, Paula J.]'s Articles
[Gibson, Raymond]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yan, Li]‘s Articles
[Ehrlich, Paula J.]‘s Articles
[Gibson, Raymond]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace