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学科主题: 公共卫生
题名:
Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population
作者: Wang, Xue-yin1; Wang, Jin-wei2; Tang, Xun1; Li, Na3; Chen, Da-fang1; Wu, Yi-qun1; Qin, Xue-ying1; Li, Jin1; Liu, Kuo1; Fang, Kai1; Hu, Yong-hua1
刊名: GENETIC TESTING AND MOLECULAR BIOMARKERS
发表日期: 2014-11-01
DOI: 10.1089/gtmb.2014.0180
卷: 18, 期:11, 页:761-766
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: CORONARY-HEART-DISEASE ; MYOCARDIAL-INFARCTION ; ATRIAL-FIBRILLATION ; HEMORRHAGIC STROKE ; RISK ; VARIANTS
英文摘要:

Background: Numerous genetic risk factors of ischemic stroke (IS) have been reported from both candidate gene and genome-wide strategies with inconsistent results. The objective of this study was to confirm the relationship between 10 previously identified single-nucleotide polymorphisms (SNPs) and IS in the Chinese population. Methods: A family-based study was conducted in a rural area of Beijing, with a total of 227 IS families with 622 participants recruited. Both linkage and association analyses were performed, with all the sibling pairs derived from the 227 families analyzed using the sib-pair test of model-free linkage to assess linkage between SNPs and IS, with association analyses including a family-based association test (FBAT) and generalized estimating equations (GEE). Results: Nonparametric linkage analysis revealed that the rs1800796 polymorphism in the interleukin-6 (IL-6) gene is significantly linked to the small arterial occlusion (SAO) subtype (p=0.022), while the rs7193343 polymorphism in the ZFHX3 gene is linked to IS (p=0.002) under the dominant model. Significant allelic associations were identified between the G allele of rs1800796 and IS (p=0.042) and the SAO subtype (p=0.025) in the FBAT. The GEE method revealed that the G allele of rs1800796 increased IS risk by 1.55-fold (95% 95% confidence interval [CI]: 1.01, 2.37; p=0.043) and 2.43-fold (95% CI: 1.32, 4.45; p=0.004) in the SAO subtype in the dominant model, which correlated with the significant associations detected in the FBAT. Conclusions: In this study, we confirmed that the SNP of rs1800796 in the IL-6 gene is related to IS and the SAO subtype using different statistical approaches. These findings could contribute to identifying individuals with a high IS risk.

语种: 英语
所属项目编号: 81230066 ; 81172744 ; 81102177 ; 30872173 ; 30671807
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000344058900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62044
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Div Nephrol, Beijing 100191, Peoples R China
3.Fangshan Dist Sci & Technol Commiss, Beijing, Peoples R China

Recommended Citation:
Wang, Xue-yin,Wang, Jin-wei,Tang, Xun,et al. Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2014,18(11):761-766.
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