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Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population
Wang, Xue-yin1; Wang, Jin-wei2; Tang, Xun1; Li, Na3; Chen, Da-fang1; Wu, Yi-qun1; Qin, Xue-ying1; Li, Jin1; Liu, Kuo1; Fang, Kai1; Hu, Yong-hua1
刊名GENETIC TESTING AND MOLECULAR BIOMARKERS
2014-11-01
DOI10.1089/gtmb.2014.0180
18期:11页:761-766
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]CORONARY-HEART-DISEASE ; MYOCARDIAL-INFARCTION ; ATRIAL-FIBRILLATION ; HEMORRHAGIC STROKE ; RISK ; VARIANTS
英文摘要

Background: Numerous genetic risk factors of ischemic stroke (IS) have been reported from both candidate gene and genome-wide strategies with inconsistent results. The objective of this study was to confirm the relationship between 10 previously identified single-nucleotide polymorphisms (SNPs) and IS in the Chinese population. Methods: A family-based study was conducted in a rural area of Beijing, with a total of 227 IS families with 622 participants recruited. Both linkage and association analyses were performed, with all the sibling pairs derived from the 227 families analyzed using the sib-pair test of model-free linkage to assess linkage between SNPs and IS, with association analyses including a family-based association test (FBAT) and generalized estimating equations (GEE). Results: Nonparametric linkage analysis revealed that the rs1800796 polymorphism in the interleukin-6 (IL-6) gene is significantly linked to the small arterial occlusion (SAO) subtype (p=0.022), while the rs7193343 polymorphism in the ZFHX3 gene is linked to IS (p=0.002) under the dominant model. Significant allelic associations were identified between the G allele of rs1800796 and IS (p=0.042) and the SAO subtype (p=0.025) in the FBAT. The GEE method revealed that the G allele of rs1800796 increased IS risk by 1.55-fold (95% 95% confidence interval [CI]: 1.01, 2.37; p=0.043) and 2.43-fold (95% CI: 1.32, 4.45; p=0.004) in the SAO subtype in the dominant model, which correlated with the significant associations detected in the FBAT. Conclusions: In this study, we confirmed that the SNP of rs1800796 in the IL-6 gene is related to IS and the SAO subtype using different statistical approaches. These findings could contribute to identifying individuals with a high IS risk.

语种英语
WOS记录号WOS:000344058900008
项目编号81230066 ; 81172744 ; 81102177 ; 30872173 ; 30671807
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62044
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学公共卫生学院_流行病与卫生统计学系
北京大学公共卫生学院_公共卫生学院
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Div Nephrol, Beijing 100191, Peoples R China
3.Fangshan Dist Sci & Technol Commiss, Beijing, Peoples R China
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GB/T 7714
Wang, Xue-yin,Wang, Jin-wei,Tang, Xun,et al. Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2014,18(11):761-766.
APA Wang, Xue-yin.,Wang, Jin-wei.,Tang, Xun.,Li, Na.,Chen, Da-fang.,...&Hu, Yong-hua.(2014).Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population.GENETIC TESTING AND MOLECULAR BIOMARKERS,18(11),761-766.
MLA Wang, Xue-yin,et al."Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population".GENETIC TESTING AND MOLECULAR BIOMARKERS 18.11(2014):761-766.
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