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学科主题: 基础医学
题名:
Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury
作者: Tan, JN; Ma, ZH; Han, L; Du, RY; Zhao, LM; Wei, X; Hou, DM; Johnstone, BH; Farlow, MR; Du, YS
关键词: apoptosis ; caspase 3 ; p38 mitogen-activated protein kinase ; tumor necrosis factor-alpha
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
发表日期: 2005-11-01
DOI: 10.1152/ajpheart.01106.2004
卷: 289, 期:5, 页:H2265-H2271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Physiology ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology ; Physiology
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; NECROSIS-FACTOR-ALPHA ; INFARCT SIZE ; CYSTEINE PROTEASE ; CELL-DEATH ; IN-VIVO ; KAPPA-B ; RAT ; APOPTOSIS ; EXPRESSION
英文摘要:

Although great achievements have been made in elucidating the molecular mechanisms contributing to acute myocardial ischemia/reperfusion (I/R) injury, an effective pharmacological therapy to protect cardiac tissues from serious damage associated with acute myocardial infarction, coronary arterial bypass grafting surgery, or acute coronary syndromes has not been developed. We examined the in vivo cardioprotective effects of caffeic acid phenethyl ester (CAPE), a natural product with potent anti-inflammatory, antitumor, and antioxidant activities. CAPE was systemically delivered to rabbits either 60 min before or 30 min after surgically inducing I/R injury. Infarct dimensions in the area at risk were reduced by > 2-fold (P < 0.01) with CAPE treatment at either period. Accordingly, serum levels of normally cytosolic enzymes lactate dehydrogenase, creatine kinase (CK), MB isoenzyme of CK, and cardiac-specific troponin I were markedly reduced in both CAPE treatment groups (P < 0.05) compared with the vehicle-treated control group. CAPE-treated tissues displayed significantly less cell death (P < 0.05), which was in part due to inhibition of p38 mitogen-activated protein kinase activation and reduced DNA fragmentation often associated with caspase 3 activation (P < 0.05). In addition, CAPE directly blocked calcium-induced cytochrome c release from mitochondria. Finally, the levels of inflammatory proteins IL-1 beta and TNF-alpha expressed in the area at risk were significantly reduced with CAPE treatment (P < 0.05). These data demonstrate that CAPE has potent cardioprotective effects against I/R injury, which are mediated, at least in part, by the inhibition of inflammatory and cell death responses. Importantly, protection is conferred when CAPE is systemically administered after the onset of ischemia, thus demonstrating potential efficacy in the clinical scenario.

语种: 英语
WOS记录号: WOS:000232497500062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62054
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Basic Med Sch, Beijing, Peoples R China
2.Peking Univ, Dept Surg, Peoples Hosp, Beijing, Peoples R China
3.Capital Med Univ, Dept Pediat Cardiol, AnZhen Hosp, Beijing, Peoples R China
4.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
5.Indiana Univ, Sch Med, Dept Med, Krannert Inst Cardiol, Indianapolis, IN 46204 USA

Recommended Citation:
Tan, JN,Ma, ZH,Han, L,et al. Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2005,289(5):H2265-H2271.
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