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Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury
Tan, JN; Ma, ZH; Han, L; Du, RY; Zhao, LM; Wei, X; Hou, DM; Johnstone, BH; Farlow, MR; Du, YS
关键词apoptosis caspase 3 p38 mitogen-activated protein kinase tumor necrosis factor-alpha
刊名AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2005-11-01
DOI10.1152/ajpheart.01106.2004
289期:5页:H2265-H2271
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Physiology ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology ; Physiology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; NECROSIS-FACTOR-ALPHA ; INFARCT SIZE ; CYSTEINE PROTEASE ; CELL-DEATH ; IN-VIVO ; KAPPA-B ; RAT ; APOPTOSIS ; EXPRESSION
英文摘要

Although great achievements have been made in elucidating the molecular mechanisms contributing to acute myocardial ischemia/reperfusion (I/R) injury, an effective pharmacological therapy to protect cardiac tissues from serious damage associated with acute myocardial infarction, coronary arterial bypass grafting surgery, or acute coronary syndromes has not been developed. We examined the in vivo cardioprotective effects of caffeic acid phenethyl ester (CAPE), a natural product with potent anti-inflammatory, antitumor, and antioxidant activities. CAPE was systemically delivered to rabbits either 60 min before or 30 min after surgically inducing I/R injury. Infarct dimensions in the area at risk were reduced by > 2-fold (P < 0.01) with CAPE treatment at either period. Accordingly, serum levels of normally cytosolic enzymes lactate dehydrogenase, creatine kinase (CK), MB isoenzyme of CK, and cardiac-specific troponin I were markedly reduced in both CAPE treatment groups (P < 0.05) compared with the vehicle-treated control group. CAPE-treated tissues displayed significantly less cell death (P < 0.05), which was in part due to inhibition of p38 mitogen-activated protein kinase activation and reduced DNA fragmentation often associated with caspase 3 activation (P < 0.05). In addition, CAPE directly blocked calcium-induced cytochrome c release from mitochondria. Finally, the levels of inflammatory proteins IL-1 beta and TNF-alpha expressed in the area at risk were significantly reduced with CAPE treatment (P < 0.05). These data demonstrate that CAPE has potent cardioprotective effects against I/R injury, which are mediated, at least in part, by the inhibition of inflammatory and cell death responses. Importantly, protection is conferred when CAPE is systemically administered after the onset of ischemia, thus demonstrating potential efficacy in the clinical scenario.

语种英语
WOS记录号WOS:000232497500062
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62054
专题北京大学基础医学院
作者单位1.Peking Univ, Basic Med Sch, Beijing, Peoples R China
2.Peking Univ, Dept Surg, Peoples Hosp, Beijing, Peoples R China
3.Capital Med Univ, Dept Pediat Cardiol, AnZhen Hosp, Beijing, Peoples R China
4.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
5.Indiana Univ, Sch Med, Dept Med, Krannert Inst Cardiol, Indianapolis, IN 46204 USA
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GB/T 7714
Tan, JN,Ma, ZH,Han, L,et al. Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2005,289(5):H2265-H2271.
APA Tan, JN.,Ma, ZH.,Han, L.,Du, RY.,Zhao, LM.,...&Du, YS.(2005).Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury.AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,289(5),H2265-H2271.
MLA Tan, JN,et al."Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury".AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 289.5(2005):H2265-H2271.
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