IR@PKUHSC  > 北京大学基础医学院  > 解剖学与组织胚胎学系
学科主题基础医学
Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters
He, MH; Cheung, ZH; Yu, EH; Tay, DKC; So, KF
关键词apoptosis ganglion cells mitochondria optic nerve signal transduction
刊名NEUROCHEMICAL RESEARCH
2004-11-01
29期:11页:2153-2161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]APOPTOSIS-INDUCING FACTOR ; BCL-2 TRANSGENIC MICE ; DEATH IN-VIVO ; NEUROTROPHIC FACTOR ; BAX PROTEIN ; SUPEROXIDE-DISMUTASE ; NEURONAL APOPTOSIS ; CEREBRAL-ISCHEMIA ; UP-REGULATION ; RAT
英文摘要

This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve ( ON) of adult hamsters was transected either at 1 or 3 mm away from the optic disc, and retrogradely labeled with Flurogold on the ON stump. After a predetermined period of postoperative time, the surviving RGCs were counted by retina flat-mount, and the activation of cytochrome c and caspase-3 were investigated by immunohistochemistry. Cell loss was found to be much faster (P < 0.01), more cells with cytochrome c were observed (P < 0.05) and the activation of caspase-3 was earlier when ON was transected 1 mm away from the optic disc than when was transected 3 mm away from the optic disc. Distance of axotomy affects the axotomized cell death rate where more RGCs died when the ON transection was applied closer to the eye. The timing of activation of caspase-3 in the RGCs may be linked to the distance of axotomy.

语种英语
WOS记录号WOS:000225538200023
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62061
Collection北京大学基础医学院_解剖学与组织胚胎学系
作者单位1.Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Anat, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
He, MH,Cheung, ZH,Yu, EH,et al. Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters[J]. NEUROCHEMICAL RESEARCH,2004,29(11):2153-2161.
APA He, MH,Cheung, ZH,Yu, EH,Tay, DKC,&So, KF.(2004).Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters.NEUROCHEMICAL RESEARCH,29(11),2153-2161.
MLA He, MH,et al."Cytochrome c release and caspase-3 activation in retinal ganglion cells following different distance of axotomy of the optic nerve in adult hamsters".NEUROCHEMICAL RESEARCH 29.11(2004):2153-2161.
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