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学科主题基础医学
Determination of paralytic shellfish poisoning toxins by HILIC-MS/MS coupled with dispersive solid phase extraction
Zhuo, Liyang1,2; Yin, Yuechun1; Fu, Wusheng3; Qiu, Bin1; Lin, Zhenyu1; Yang, Yiqiang2; Zheng, Lemin4,5,6; Li, Jianrong7; Chen, Guonan1
关键词Paralytic shellfish poisoning toxins Hydrophilic interaction liquid chromatography Tandem mass spectrometry Dispersive solid phase extraction
刊名FOOD CHEMISTRY
2013-03-01
DOI10.1016/j.foodchem.2012.10.010
137期:1-4页:115-121
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]LIQUID-CHROMATOGRAPHY
英文摘要

This paper describes the use of QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) for the extraction, cleanup and detection of 10 paralytic shellfish toxins (PSP) in sea food by HILIC-MS/MS with positive ESI. Matrix matched calibration standards were used to compensate for matrix effects. The toxins were extracted with acetonitrile/water (90:10, v/v) containing 0.1% formic acid and cleaned by HLB and GCB sorbents. Qualitative and quantitative detection for the analytes were carried out under the multiple reaction monitoring (MRM) in positive ionization mode after chromatography separation on a TSK-gel Amide-80 (R) column (150 mm x 2.0 mm x 3 mu m). Studies at three fortification levels for the toxins in the range of 8.1-225.5 mu g/kg gave mean recoveries from 71.3% to 104.6% with relative standard deviation (RSD) <= 15.8%. The limit of detection (LOD) was below the recommended regulatory limit of 170 mu g STXequ/kg and the proposed method fully meets the needs of daily monitoring. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000313386400016
项目编号2010QK024 ; FJQI2009005 ; 2012BAD29B06 ; 2011N5008 ; IRT1116
资助机构General Administration of Quality Supervision, Inspection and Quarantine of China ; Fujian Provincial Bureau of Quality and Technical Supervision ; National Key Technologies R&amp ; D Program of China during the 12th Five-Year Plan Period ; Major Project of Fujian Province ; Program for Changjiang Scholars and Innovative Research Team in University
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62062
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Qual Inspect Inst Quanzhou, Quanzhou 362000, Fujian, Peoples R China
2.Fujian Ctr Dis Control & Prevent, Fuzhou 350001, Fujian, Peoples R China
3.Fuzhou Univ, Key Lab Anal & Detect Technol Food Safety, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ,Dept Chem, Fuzhou 350002, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Sch Basic Med Sci, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Sch Basic Med Sci, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
7.Zhejiang Gongshang Univ, Food Safety Key Lab Zhejiang Prov, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China
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GB/T 7714
Zhuo, Liyang,Yin, Yuechun,Fu, Wusheng,et al. Determination of paralytic shellfish poisoning toxins by HILIC-MS/MS coupled with dispersive solid phase extraction[J]. FOOD CHEMISTRY,2013,137(1-4):115-121.
APA Zhuo, Liyang.,Yin, Yuechun.,Fu, Wusheng.,Qiu, Bin.,Lin, Zhenyu.,...&Chen, Guonan.(2013).Determination of paralytic shellfish poisoning toxins by HILIC-MS/MS coupled with dispersive solid phase extraction.FOOD CHEMISTRY,137(1-4),115-121.
MLA Zhuo, Liyang,et al."Determination of paralytic shellfish poisoning toxins by HILIC-MS/MS coupled with dispersive solid phase extraction".FOOD CHEMISTRY 137.1-4(2013):115-121.
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