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学科主题: 临床医学
题名:
Nodular goiter surface detection by FTIR spectroscopy
作者: Ling, XF; Xu, Z; Xu, YZ; Zhou, S; Zhang, NW; Wang, LX; Hou, CS; Zhang, YF; Zhou, XS; Wu, JG
关键词: nodular goiter ; FTIR spectroscopy ; surface detection
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2005-12-01
卷: 25, 期:12, 页:1955-1958
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: TRANSFORM INFRARED-SPECTROSCOPY ; IN-VIVO ; CANCER ; TUMOR
英文摘要:

A novel non-invasive diagnosis method of nodular goiter is proposed in the present study by recording F-FIR spectra on the skin overlying thyroids using fiber optical technique and attenuated total reflection probe. FTIR spectra from 20 nodular goiters and 34 normal controls were collected. Twenty seven-spectral variables of 13 bands including peak position and relative intensities were extracted from the FTIR spectra so that statistic work could be conducted using SPSS. The results demonstrate that peak positions of 2925 and 1250 cm(-1) both shifted toward lower wave number(P < 0.05) in the FTIR spectra of nodular goiter. The relative intensity ratios of H-1740/H-1460, H-1160/H-1460, and H-1160/H-1120 decreased significantly in FTIR spectra of nodular goiter (P < 0.05). Inversely, H-1080/H-1460 increased significantly (P < 0.05) in nodular goiter. The above statistic differences suggest that nodular goiter may produce some characteristic chemical substance which can diffuse onto the surface of skin and therefore be detectable using FTIR spectroscopy with fiber optic techniques. These differences are the basis of diagnosing nodular goiter by FTIR surface detection.

语种: 中文
WOS记录号: WOS:000234388500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62064
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Coll Chem, Beijing 100871, Peoples R China
2.Beijing Shijitan Hosp, Dept Gen Surg, Beijing 100038, Peoples R China
3.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100083, Peoples R China

Recommended Citation:
Ling, XF,Xu, Z,Xu, YZ,et al. Nodular goiter surface detection by FTIR spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2005,25(12):1955-1958.
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