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Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial
Wang, Y.1; Fu, H-X1; Liu, D-H1; Xu, L-P1; Zhang, X-H1; Chang, Y-J1; Chen, Y-H1; Wang, F-R1; Sun, Y-Q1; Tang, F-F1; Liu, K-Y1; Huang, X-J1,2
关键词antithymocyte globulin HLA-mismatched transplantation
刊名BONE MARROW TRANSPLANTATION
2014-03-01
DOI10.1038/bmt.2013.191
49期:3页:426-433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; MATCHED-PAIR ANALYSIS ; UNRELATED DONORS ; ACUTE-LEUKEMIA ; HEMATOPOIETIC TRANSPLANTATION ; GRAFT ; RECIPIENTS
英文摘要

To evaluate the effect of the different doses of antithymocyte globulin (ATG) on the incidence of acute GVHD among patients receiving hematopoietic SCT without ex vivo T-cell-depletion from haploidentical donors, 224 patients with standard-risk hematological malignancy were randomized in this study. One hundred and twelve patients received 6 mg/kg ATG, whereas the remaining patients received 10 mg/kg ATG. This study was registered at http://www.chictr.org as No. ChiCTR-TRC-11001761. The incidence of grade III-IV acute GVHD was higher in the ATG-6 group (16.1%, 95% confidence interval (CI), 9.1-23.1%) than in the ATG-10 group (4.5%, CI, 0.7-8.3%, P = 0.005, 95% CI for the difference, - 19.4% to - 3.8%). EBV reactivation occurred more frequently in the ATG- 10 group (25.3%, 17.1-33.5%) than in the ATG- 6 group (9.6% (4.0-15.2%), P = 0.001). The 1-year disease-free survival rates were 84.3% (77.3-91.3%) and 86.0% (79.2-92.8%) for the ATG- 6 group and ATG- 10 groups, respectively (P = 0.88). In conclusion, although 6 mg/kg ATG applied in haploidentical transplantation decreased the risk of EBV reactivation compared with 10 mg/kg ATG, this treatment exposes patients to a higher risk for severe acute GVHD.

语种英语
WOS记录号WOS:000332638100018
项目编号2011AA020105 ; 81230013 ; 20114022-08 ; 30971292 ; 30725038
资助机构National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; National Natural Science Foundation of China
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62070
专题北京大学第二临床医学院_血液科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Y.,Fu, H-X,Liu, D-H,et al. Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial[J]. BONE MARROW TRANSPLANTATION,2014,49(3):426-433.
APA Wang, Y..,Fu, H-X.,Liu, D-H.,Xu, L-P.,Zhang, X-H.,...&Huang, X-J.(2014).Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial.BONE MARROW TRANSPLANTATION,49(3),426-433.
MLA Wang, Y.,et al."Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial".BONE MARROW TRANSPLANTATION 49.3(2014):426-433.
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