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学科主题: 药学
题名:
Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis
作者: Zhang, Hua1; Hu, Hongxiang1; Zhang, Haoran1; Dai, Wenbing1; Wang, Xinglin2; Wang, Xueqing1; Zhang, Qiang1
刊名: NANOSCALE
发表日期: 2015
DOI: 10.1039/c4nr07450e
卷: 7, 期:24, 页:10790-10800
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: DRUG-DELIVERY SYSTEMS ; CAMPTOTHECIN NANOCRYSTALS ; PEG ; NANOPARTICLES ; FORMULATION ; CONJUGATE ; ANTITUMOR ; PHARMACOKINETICS ; NANOSUSPENSION ; CHEMOTHERAPY
英文摘要:

As an attractive strategy developed rapidly in recent years, nanocrystals are used to deliver insoluble drugs. PEGylation may further prolong the circulation time of nanoparticles and improve the therapeutic outcome of drugs. In this study, paclitaxel (PTX) nanocrystals (PTX-NCs) and PEGylated PTX nanocrystals (PEG-PTX-NCs) were prepared using antisolvent precipitation augmented by probe sonication. The characteristics and antitumor efficacy of nanocrystals were investigated. The results indicated that the nanocrystals showed rod-like morphology, and the average particle size was 240 nm and 330 nm for PTX-NCs and PEG-PTX-NCs, respectively. The PEG molecules covered the surface of nanocrystals with an 11.54 nm fixed aqueous layer thickness (FALT), much higher than that of PTX-NCs (0.2 nm). PEG-PTX-NCs showed higher stability than PTX-NCs under both storage and physiological conditions. In breast cancer xenografted mice, PEG-PTX-NCs showed significantly better tumor inhibition compared to saline (p < 0.001) and PTX-NC groups (p < 0.05) after intravenous administration. In a model of lung tumor metastasis quantified by the luciferase activity, the PEG-PTX-NCs group showed higher anticancer efficacy not only than saline and PTX-NCs groups, but also than Taxol (R), achieving an 82% reduction at the end of the experiment. These studies suggested the potential advantages of PEGylated PTX nanocrystals as alternative drug delivery systems for anticancer therapy.

语种: 英语
所属项目编号: 81202470 ; 81130059 ; 2015CB932100
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 program)
WOS记录号: WOS:000356058600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62076
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China

Recommended Citation:
Zhang, Hua,Hu, Hongxiang,Zhang, Haoran,et al. Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis[J]. NANOSCALE,2015,7(24):10790-10800.
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