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学科主题临床医学
Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes
Hou, Feng-Qin1,2; Zeng, Zheng1,2; Wang, Gui-Qiang1,2
关键词Drugs Liver injury Steroid therapy
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2012-11-01
DOI10.1007/s12013-012-9373-y
64期:2页:77-83
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]TERM-FOLLOW-UP ; HEPATIC-FAILURE ; UNITED-STATES ; JAUNDICE ; TRANSPLANTATION ; HEPATOTOXICITY ; PROGNOSIS ; REGISTRY ; SWEDEN ; PERIOD
英文摘要

We investigated clinical features, therapy, and outcomes of patients hospitalized for drug-induced liver injury (DILI). DILI resolution was defined as liver biochemistry values back to normal or lower than CIOMS laboratory criteria; Chronicity was defined as persistent biochemical abnormality for > 6 months after drugs′ withdrawal. Three-hundred cases were reviewed retrospectively; mean age 51 (13-86) years, and 204 (68 %) were females. It included 267 (89 %) hepatocellular injury, 16 (5.3 %) cholestatic injury, and 17 (5.7 %) mixed injury cases. In hepatocellular injury group, 197 (73.8 %) patients with TBIL < 10x ULN included 142 (72.1 %) females and 70 (26.2 %) patients with TBIL a parts per thousand yen 10x ULN included 39 (55.7 %) females (P = 0.012). Of 70 patients (TBIL a parts per thousand yen 10x ULN), 20 were treated with steroid step-down therapy (79 +/- A 26 days) and others with non-steroid therapy. The steroid therapy group showed higher DILI resolution rate (P = 0.029) and shorter recovery time (P = 0.012). Notably, 274/300 (91.3 %) patients resolved, 18/300 (6 %) developed chronic liver injury, 7/300 (2.3 %) died, and one patient received liver transplantation. In death group, TBIL, ALB, PT, and PTA revealed more severe abnormality than in recovery group. In 121/300 (40.3 %) patients, use of herbal medicines was the leading cause of liver injury, followed by antibiotics, cardiovascular drugs, and endocrine drugs. We concluded that step-down steroid therapy for DILI improved curative effect, shortened disease course, and was safe.

语种英语
WOS记录号WOS:000309865500002
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62077
专题北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100034, Peoples R China
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GB/T 7714
Hou, Feng-Qin,Zeng, Zheng,Wang, Gui-Qiang. Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2012,64(2):77-83.
APA Hou, Feng-Qin,Zeng, Zheng,&Wang, Gui-Qiang.(2012).Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes.CELL BIOCHEMISTRY AND BIOPHYSICS,64(2),77-83.
MLA Hou, Feng-Qin,et al."Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes".CELL BIOCHEMISTRY AND BIOPHYSICS 64.2(2012):77-83.
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