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学科主题: 临床医学
题名:
Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes
作者: Hou, Feng-Qin1,2; Zeng, Zheng1,2; Wang, Gui-Qiang1,2
关键词: Drugs ; Liver injury ; Steroid therapy
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2012-11-01
DOI: 10.1007/s12013-012-9373-y
卷: 64, 期:2, 页:77-83
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: TERM-FOLLOW-UP ; HEPATIC-FAILURE ; UNITED-STATES ; JAUNDICE ; TRANSPLANTATION ; HEPATOTOXICITY ; PROGNOSIS ; REGISTRY ; SWEDEN ; PERIOD
英文摘要:

We investigated clinical features, therapy, and outcomes of patients hospitalized for drug-induced liver injury (DILI). DILI resolution was defined as liver biochemistry values back to normal or lower than CIOMS laboratory criteria; Chronicity was defined as persistent biochemical abnormality for > 6 months after drugs′ withdrawal. Three-hundred cases were reviewed retrospectively; mean age 51 (13-86) years, and 204 (68 %) were females. It included 267 (89 %) hepatocellular injury, 16 (5.3 %) cholestatic injury, and 17 (5.7 %) mixed injury cases. In hepatocellular injury group, 197 (73.8 %) patients with TBIL < 10x ULN included 142 (72.1 %) females and 70 (26.2 %) patients with TBIL a parts per thousand yen 10x ULN included 39 (55.7 %) females (P = 0.012). Of 70 patients (TBIL a parts per thousand yen 10x ULN), 20 were treated with steroid step-down therapy (79 +/- A 26 days) and others with non-steroid therapy. The steroid therapy group showed higher DILI resolution rate (P = 0.029) and shorter recovery time (P = 0.012). Notably, 274/300 (91.3 %) patients resolved, 18/300 (6 %) developed chronic liver injury, 7/300 (2.3 %) died, and one patient received liver transplantation. In death group, TBIL, ALB, PT, and PTA revealed more severe abnormality than in recovery group. In 121/300 (40.3 %) patients, use of herbal medicines was the leading cause of liver injury, followed by antibiotics, cardiovascular drugs, and endocrine drugs. We concluded that step-down steroid therapy for DILI improved curative effect, shortened disease course, and was safe.

语种: 英语
WOS记录号: WOS:000309865500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62077
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100034, Peoples R China

Recommended Citation:
Hou, Feng-Qin,Zeng, Zheng,Wang, Gui-Qiang. Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2012,64(2):77-83.
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