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学科主题: 基础医学
题名:
Girdin locates in centrosome and midbody and plays an important role in cell division
作者: Mao, Jing-Zhuo1; Jiang, Ping1,2,3; Cui, Su-Ping1; Ren, Ya-Li4; Zhao, Jing1; Yin, Xiu-Hua5; Enomoto, Atsushi6; Liu, Hai-Jing1; Hou, Lin1; Takahashi, Masahide6; Zhang, Bo1
刊名: CANCER SCIENCE
发表日期: 2012-10-01
DOI: 10.1111/j.1349-7006.2012.02378.x
卷: 103, 期:10, 页:1780-1787
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EPIDERMAL-GROWTH-FACTOR ; ACTIN-BINDING PROTEIN ; BREAST-CANCER CELLS ; G-ALPHA-I ; FACTOR RECEPTOR ; MIGRATION ; AKT ; CYTOKINESIS ; EGF ; GIV
英文摘要:

Girdin is a downstream effector of epidermal growth factor receptor (EGFR)-AKT and interacts with actin and microtubule. Increasing evidence confirmed that Girdin played an important role in cell migration. Here we report that Girdin also regulates cell division. Overexpression or suppression of Girdin leads to attenuated cell proliferation. Imaging of mitotic cells revealed that Girdin is located in the cell division apparatus such as centrosome and midbody. The sub-cellular localization of Girdin was dependent on the domains, which interacted with actin or microtubules. Overexpression of Girdin lead to increased centrosome splitting and amplification. In addition, data show that pAKT also locates in both the centrosome and midbody, indicating the regulating role of AKT in Girdin-mediated cell division. To elucidate the effect of Girdin on tumor growth in vivo, HeLa cells infected with retrovirus harboring either control or Girdin shRNAs were injected subcutaneously into the immunocompromised nude mice. Downregulation of Girdin by shRNA markedly inhibited the cell growth of subcutaneously transplanted tumors in nude mice. These data demonstrate that Girdin is important for efficient cell division. Taking our previous data into consideration, we speculate that Girdin regulates both cell division and cell migration through cytoskeletal molecules.

语种: 英语
所属项目编号: 30770830 ; 81072172 ; 20100470170 ; 201104043
项目资助者: National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000309600400006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62078
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Beijing Hosp, Key Lab Geriatr, Beijing, Peoples R China
2.Minist Hlth, Beijing Inst Geriatr, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Lab Elect Microscopy, Beijing 100871, Peoples R China
5.Shandong Coll Tradit Chinese Med, Teaching Dept Western Med, Jinan, Shandong, Peoples R China
6.Nagoya Univ, Grad Sch Med, Dept Pathol, Nagoya, Aichi 4648601, Japan

Recommended Citation:
Mao, Jing-Zhuo,Jiang, Ping,Cui, Su-Ping,et al. Girdin locates in centrosome and midbody and plays an important role in cell division[J]. CANCER SCIENCE,2012,103(10):1780-1787.
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