IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Girdin locates in centrosome and midbody and plays an important role in cell division
Mao, Jing-Zhuo1; Jiang, Ping1,2,3; Cui, Su-Ping1; Ren, Ya-Li4; Zhao, Jing1; Yin, Xiu-Hua5; Enomoto, Atsushi6; Liu, Hai-Jing1; Hou, Lin1; Takahashi, Masahide6; Zhang, Bo1
刊名CANCER SCIENCE
2012-10-01
DOI10.1111/j.1349-7006.2012.02378.x
103期:10页:1780-1787
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; ACTIN-BINDING PROTEIN ; BREAST-CANCER CELLS ; G-ALPHA-I ; FACTOR RECEPTOR ; MIGRATION ; AKT ; CYTOKINESIS ; EGF ; GIV
英文摘要

Girdin is a downstream effector of epidermal growth factor receptor (EGFR)-AKT and interacts with actin and microtubule. Increasing evidence confirmed that Girdin played an important role in cell migration. Here we report that Girdin also regulates cell division. Overexpression or suppression of Girdin leads to attenuated cell proliferation. Imaging of mitotic cells revealed that Girdin is located in the cell division apparatus such as centrosome and midbody. The sub-cellular localization of Girdin was dependent on the domains, which interacted with actin or microtubules. Overexpression of Girdin lead to increased centrosome splitting and amplification. In addition, data show that pAKT also locates in both the centrosome and midbody, indicating the regulating role of AKT in Girdin-mediated cell division. To elucidate the effect of Girdin on tumor growth in vivo, HeLa cells infected with retrovirus harboring either control or Girdin shRNAs were injected subcutaneously into the immunocompromised nude mice. Downregulation of Girdin by shRNA markedly inhibited the cell growth of subcutaneously transplanted tumors in nude mice. These data demonstrate that Girdin is important for efficient cell division. Taking our previous data into consideration, we speculate that Girdin regulates both cell division and cell migration through cytoskeletal molecules.

语种英语
WOS记录号WOS:000309600400006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62078
专题北京大学基础医学院_病理学系
北京大学第一临床医学院_电镜室
作者单位1.Beijing Hosp, Key Lab Geriatr, Beijing, Peoples R China
2.Minist Hlth, Beijing Inst Geriatr, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Lab Elect Microscopy, Beijing 100871, Peoples R China
5.Shandong Coll Tradit Chinese Med, Teaching Dept Western Med, Jinan, Shandong, Peoples R China
6.Nagoya Univ, Grad Sch Med, Dept Pathol, Nagoya, Aichi 4648601, Japan
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GB/T 7714
Mao, Jing-Zhuo,Jiang, Ping,Cui, Su-Ping,et al. Girdin locates in centrosome and midbody and plays an important role in cell division[J]. CANCER SCIENCE,2012,103(10):1780-1787.
APA Mao, Jing-Zhuo.,Jiang, Ping.,Cui, Su-Ping.,Ren, Ya-Li.,Zhao, Jing.,...&Zhang, Bo.(2012).Girdin locates in centrosome and midbody and plays an important role in cell division.CANCER SCIENCE,103(10),1780-1787.
MLA Mao, Jing-Zhuo,et al."Girdin locates in centrosome and midbody and plays an important role in cell division".CANCER SCIENCE 103.10(2012):1780-1787.
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