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学科主题药学
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway
She, Tiantian1; Zhao, Chuanke1; Feng, Junnan1; Wang, Lixin1; Qu, Like1; Fang, Ke1; Cai, Shaoqing2; Shou, Chengchao1
刊名PLOS ONE
2015-03-05
DOI10.1371/journal.pone.0118287
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China ; National Basic Research Program of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FOCAL ADHESION KINASE ; AQUEOUS EXTRACT ; TNF-ALPHA ; TGF-BETA ; GROWTH ; HYPERSENSITIVITY ; NEUROTENSIN ; METASTASIS ; EXPRESSION ; SECRETION
英文摘要

Sarsaparilla, also known as Smilax Glabra Rhizome (SGR), was shown to modulate immunity, protect against liver injury, lower blood glucose and suppress cancer. However, its effects on cancer cell adhesion, migration and invasion were unclear. In the present study, we found that the supernatant of water-soluble extract from SGR (SW) could promote adhesion, inhibit migration and invasion of HepG2, MDA-MB-231 and T24 cells in vitro, as well as suppress metastasis of MDA-MB-231 cells in vivo. Results of F-actin and vinculin dual staining showed the enhanced focal adhesion in SW-treated cells. Microarray analysis indicated a repression of TGF-beta 1 signaling by SW treatment, which was verified by real-time RT-PCR of TGF-beta 1-related genes and immunoblotting of TGFBR1 protein. SW was also shown to antagonize TGF-beta 1-promoted cell migration. Collectively, our study revealed a new antitumor function of Sarsaparilla in counteracting invasiveness of a subset of cancer cells by inhibiting TGF-beta 1 signaling.

语种英语
所属项目编号2010CB529303 ; 2013CB910504
资助者National Basic Research Program of China ; National Basic Research Program of China
WOS记录号WOS:000350688100011
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62081
Collection北京大学药学院
作者单位1.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
She, Tiantian,Zhao, Chuanke,Feng, Junnan,et al. Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway[J]. PLOS ONE,2015,10(3).
APA She, Tiantian.,Zhao, Chuanke.,Feng, Junnan.,Wang, Lixin.,Qu, Like.,...&Shou, Chengchao.(2015).Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway.PLOS ONE,10(3).
MLA She, Tiantian,et al."Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway".PLOS ONE 10.3(2015).
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