IR@PKUHSC  > 北京大学药学院
学科主题药学
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway
She, Tiantian1; Zhao, Chuanke1; Feng, Junnan1; Wang, Lixin1; Qu, Like1; Fang, Ke1; Cai, Shaoqing2; Shou, Chengchao1
刊名PLOS ONE
2015-03-05
DOI10.1371/journal.pone.0118287
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China ; National Basic Research Program of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FOCAL ADHESION KINASE ; AQUEOUS EXTRACT ; TNF-ALPHA ; TGF-BETA ; GROWTH ; HYPERSENSITIVITY ; NEUROTENSIN ; METASTASIS ; EXPRESSION ; SECRETION
英文摘要

Sarsaparilla, also known as Smilax Glabra Rhizome (SGR), was shown to modulate immunity, protect against liver injury, lower blood glucose and suppress cancer. However, its effects on cancer cell adhesion, migration and invasion were unclear. In the present study, we found that the supernatant of water-soluble extract from SGR (SW) could promote adhesion, inhibit migration and invasion of HepG2, MDA-MB-231 and T24 cells in vitro, as well as suppress metastasis of MDA-MB-231 cells in vivo. Results of F-actin and vinculin dual staining showed the enhanced focal adhesion in SW-treated cells. Microarray analysis indicated a repression of TGF-beta 1 signaling by SW treatment, which was verified by real-time RT-PCR of TGF-beta 1-related genes and immunoblotting of TGFBR1 protein. SW was also shown to antagonize TGF-beta 1-promoted cell migration. Collectively, our study revealed a new antitumor function of Sarsaparilla in counteracting invasiveness of a subset of cancer cells by inhibiting TGF-beta 1 signaling.

语种英语
所属项目编号2010CB529303 ; 2013CB910504
资助者National Basic Research Program of China ; National Basic Research Program of China
WOS记录号WOS:000350688100011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62081
专题北京大学药学院
作者单位1.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
She, Tiantian,Zhao, Chuanke,Feng, Junnan,et al. Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway[J]. PLOS ONE,2015,10(3).
APA She, Tiantian.,Zhao, Chuanke.,Feng, Junnan.,Wang, Lixin.,Qu, Like.,...&Shou, Chengchao.(2015).Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway.PLOS ONE,10(3).
MLA She, Tiantian,et al."Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway".PLOS ONE 10.3(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[She, Tiantian]的文章
[Zhao, Chuanke]的文章
[Feng, Junnan]的文章
百度学术
百度学术中相似的文章
[She, Tiantian]的文章
[Zhao, Chuanke]的文章
[Feng, Junnan]的文章
必应学术
必应学术中相似的文章
[She, Tiantian]的文章
[Zhao, Chuanke]的文章
[Feng, Junnan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。