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学科主题: 药学
题名:
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway
作者: She, Tiantian1; Zhao, Chuanke1; Feng, Junnan1; Wang, Lixin1; Qu, Like1; Fang, Ke1; Cai, Shaoqing2; Shou, Chengchao1
刊名: PLOS ONE
发表日期: 2015-03-05
DOI: 10.1371/journal.pone.0118287
卷: 10, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FOCAL ADHESION KINASE ; AQUEOUS EXTRACT ; TNF-ALPHA ; TGF-BETA ; GROWTH ; HYPERSENSITIVITY ; NEUROTENSIN ; METASTASIS ; EXPRESSION ; SECRETION
英文摘要:

Sarsaparilla, also known as Smilax Glabra Rhizome (SGR), was shown to modulate immunity, protect against liver injury, lower blood glucose and suppress cancer. However, its effects on cancer cell adhesion, migration and invasion were unclear. In the present study, we found that the supernatant of water-soluble extract from SGR (SW) could promote adhesion, inhibit migration and invasion of HepG2, MDA-MB-231 and T24 cells in vitro, as well as suppress metastasis of MDA-MB-231 cells in vivo. Results of F-actin and vinculin dual staining showed the enhanced focal adhesion in SW-treated cells. Microarray analysis indicated a repression of TGF-beta 1 signaling by SW treatment, which was verified by real-time RT-PCR of TGF-beta 1-related genes and immunoblotting of TGFBR1 protein. SW was also shown to antagonize TGF-beta 1-promoted cell migration. Collectively, our study revealed a new antitumor function of Sarsaparilla in counteracting invasiveness of a subset of cancer cells by inhibiting TGF-beta 1 signaling.

语种: 英语
所属项目编号: 2010CB529303 ; 2013CB910504
项目资助者: National Basic Research Program of China
WOS记录号: WOS:000350688100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62081
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
She, Tiantian,Zhao, Chuanke,Feng, Junnan,et al. Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-beta 1 Pathway[J]. PLOS ONE,2015,10(3).
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