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学科主题: 基础医学
题名:
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
作者: Kong, Yaxian1,2; Wang, Hong3; Wang, Shuling3; Tang, Na3
关键词: FTY720 ; liver fibrosis ; bone marrow-derived mesenchymal stem cells (BMSCs) ; sphingosine-1 phosphate (S1P)
刊名: INFLAMMATION
发表日期: 2014-08-01
DOI: 10.1007/s10753-014-9877-2
卷: 37, 期:4, 页:1326-1336
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: CHEMICAL-INDUCED HEPATOTOXICITY ; GROWTH-FACTOR ; IMMUNOMODULATOR FTY720 ; MULTIPLE-SCLEROSIS ; LYMPHOCYTE EGRESS ; LUNG FIBROBLASTS ; STROMAL CELLS ; CROSS-TALK ; 1-PHOSPHATE ; INFLAMMATION
英文摘要:

FTY720 is a novel immunosuppressant that modulates sphingosine 1-phosphate (S1P) receptors for the treatment of several diseases. Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis. However, whether these treatment strategies suppress liver fibrosis progression is incompletely understood. Here, we investigated the effects and mechanisms by which FTY720 improves liver fibrosis in the carbon tetrachloride (CCl4)-induced mouse model. FTY720 treatment significantly attenuated the expression of fibrotic markers in the injured liver of both wild-type and SCID-beige mice. The migration of bone marrow-derived mesenchymal stem cells (BMSCs) to circulation, and subsequently the injured liver, was suppressed by FTY720. Furthermore, in vitro, phosphorylated-FTY720 blocked the migration of BMSCs mediated by S1P. Thus, FTY720 is an effective therapy for liver fibrosis via the suppression of BMSC migration in the CCl4-induced mouse model.

语种: 英语
所属项目编号: 2009DFB30300
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000338725600039
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62088
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: 1.Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100191, Peoples R China
3.Capital Med Univ, Inst Infect Dis, Beijing Ditan Hosp, Beijing 100015, Peoples R China

Recommended Citation:
Kong, Yaxian,Wang, Hong,Wang, Shuling,et al. FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells[J]. INFLAMMATION,2014,37(4):1326-1336.
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