IR@PKUHSC  > 北京大学基础医学院  > 北京大学干细胞研究中心
学科主题基础医学
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
Kong, Yaxian1,2; Wang, Hong3; Wang, Shuling3; Tang, Na3
关键词FTY720 liver fibrosis bone marrow-derived mesenchymal stem cells (BMSCs) sphingosine-1 phosphate (S1P)
刊名INFLAMMATION
2014-08-01
DOI10.1007/s10753-014-9877-2
37期:4页:1326-1336
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]CHEMICAL-INDUCED HEPATOTOXICITY ; GROWTH-FACTOR ; IMMUNOMODULATOR FTY720 ; MULTIPLE-SCLEROSIS ; LYMPHOCYTE EGRESS ; LUNG FIBROBLASTS ; STROMAL CELLS ; CROSS-TALK ; 1-PHOSPHATE ; INFLAMMATION
英文摘要

FTY720 is a novel immunosuppressant that modulates sphingosine 1-phosphate (S1P) receptors for the treatment of several diseases. Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis. However, whether these treatment strategies suppress liver fibrosis progression is incompletely understood. Here, we investigated the effects and mechanisms by which FTY720 improves liver fibrosis in the carbon tetrachloride (CCl4)-induced mouse model. FTY720 treatment significantly attenuated the expression of fibrotic markers in the injured liver of both wild-type and SCID-beige mice. The migration of bone marrow-derived mesenchymal stem cells (BMSCs) to circulation, and subsequently the injured liver, was suppressed by FTY720. Furthermore, in vitro, phosphorylated-FTY720 blocked the migration of BMSCs mediated by S1P. Thus, FTY720 is an effective therapy for liver fibrosis via the suppression of BMSC migration in the CCl4-induced mouse model.

语种英语
所属项目编号2009DFB30300
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
WOS记录号WOS:000338725600039
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62088
Collection北京大学基础医学院_北京大学干细胞研究中心
作者单位1.Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100191, Peoples R China
3.Capital Med Univ, Inst Infect Dis, Beijing Ditan Hosp, Beijing 100015, Peoples R China
Recommended Citation
GB/T 7714
Kong, Yaxian,Wang, Hong,Wang, Shuling,et al. FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells[J]. INFLAMMATION,2014,37(4):1326-1336.
APA Kong, Yaxian,Wang, Hong,Wang, Shuling,&Tang, Na.(2014).FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells.INFLAMMATION,37(4),1326-1336.
MLA Kong, Yaxian,et al."FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells".INFLAMMATION 37.4(2014):1326-1336.
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