IR@PKUHSC  > 北京大学药学院
学科主题药学
Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus
Ye, M; Han, J; Tu, GZ; An, DG; Guo, D
刊名JOURNAL OF NATURAL PRODUCTS
2005-04-01
68期:4页:626-628
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]HUMAN LEUKEMIA-CELLS ; CATHARANTHUS-ROSEUS ; BUFADIENOLIDES ; CINOBUFAGIN
英文摘要

The microbial transformation of a cytotoxic bufadienolide, bufalin (1), was carried out using two strains of filamentous fungi. Cunninghamella blakesleana catalyzed the specific 12 alpha-hydroxylation of bufalin and produced 12 alpha-hydroxybufalin (2) and 7 beta,12 alpha-dihydroxybufalin (3) as the major metabolites, together with 7 beta-hydroxybufalin (4) and 12 beta-hydroxybufalin (5) in low yields. Two minor products were isolated from the culture broth of Mucor spinosus and were identified as 7 beta,15 alpha-dihydroxybufalin (6) and 5 beta,7 beta-dihydroxybufalin (7), respectively. Metabolites 2, 3, 6, and 7 are new compounds, and their structures were fully characterized by NMR and MS spectroscopy.

语种英语
WOS记录号WOS:000228677000035
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62089
Collection北京大学药学院
作者单位1.Beijing Inst Microchem, Beijing 100091, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Ye, M,Han, J,Tu, GZ,et al. Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(4):626-628.
APA Ye, M,Han, J,Tu, GZ,An, DG,&Guo, D.(2005).Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus.JOURNAL OF NATURAL PRODUCTS,68(4),626-628.
MLA Ye, M,et al."Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus".JOURNAL OF NATURAL PRODUCTS 68.4(2005):626-628.
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