IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: a multicenter and open-labeled phase IIa study
Zhao, Yi1; Zhou, Zhanchao2,3; Zhou, Guoyu4; Tu, Ping1; Zheng, Qingshan5; Tao, Jining6; Gu, Ying7; Zhu, Xuejun1
关键词hematoporphyrin monomethyl ether hemoporfin HMME photochemotherapy photodynamic therapy port-wine stain
刊名PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
2011-02-01
DOI10.1111/j.1600-0781.2010.00555.x
27期:1页:17-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]PULSED DYE-LASER ; BIRTHMARKS ; PDT
英文摘要

Background/purpose

This phase IIa study aimed to study the efficacy and safety of hemoporfin in photodynamic therapy (PDT) with a 532 nm continuous laser for port-wine stain (PWS).

Methods

In this 8-week open-labeled study in three centers, three different laser exposure times (532 nm continuous laser for 20, 30 and 40 min) were used in stage I, group A, stage II, group B and stage III, group C, respectively. Primary efficacy assessment was performed by an independent group of experts, who reviewed the standardized photos. Secondary efficacy assessment consisted of the subjective grading of the PWS fading by the investigators and the patients. Treatment reactions and adverse events (AE) were recorded separately.

Results

Forty patients were initially enrolled in the study, but stage III had to be cancelled eventually for the safety of the patients. Patients in groups A and B showed similar satisfactory results in efficacy assessments, the total ′response′ rate being 80.0% and 94.7% in groups A and B, respectively. The AE rates were also similar in the two groups. Self-limiting photosensitive dermatitis and hyperpigmentation were the most frequently observed AE.

Conclusion

Hemoporfin-PDT is effective and safe for patients with PWS aged 16-50.

语种英语
WOS记录号WOS:000285875000003
资助机构Shanghai Fudan-zhangjiang Bio-Pharmaceutical Co Ltd
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62090
专题北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
2.Chinese Acad Med Sci, Inst Dermatol, Nanjing, Peoples R China
3.Peking Union Med Coll, Nanjing, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Oral Maxillofacial Surg, Shanghai 200030, Peoples R China
5.Shanghai Univ, TCM, Ctr Drug Clin Res, Shanghai, Peoples R China
6.Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, Shanghai, Peoples R China
7.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing, Peoples R China
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GB/T 7714
Zhao, Yi,Zhou, Zhanchao,Zhou, Guoyu,et al. Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: a multicenter and open-labeled phase IIa study[J]. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE,2011,27(1):17-23.
APA Zhao, Yi.,Zhou, Zhanchao.,Zhou, Guoyu.,Tu, Ping.,Zheng, Qingshan.,...&Zhu, Xuejun.(2011).Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: a multicenter and open-labeled phase IIa study.PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE,27(1),17-23.
MLA Zhao, Yi,et al."Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: a multicenter and open-labeled phase IIa study".PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE 27.1(2011):17-23.
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