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学科主题临床医学
Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy
Xu Gang; Xu Bo; Zhang Shan-wen
关键词rectal cancer tumor infiltrating lymphocyte preoperative radiotherapy local control prognosis immunohistochemistry downstaging
刊名CHINESE JOURNAL OF CANCER RESEARCH
2008-09-01
DOI10.1007/S11670-008-0222-X
20期:3页:222-229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; COLORECTAL-CANCER ; ESOPHAGEAL-CARCINOMA ; PROGNOSTIC FACTORS ; FAS COUNTERATTACK ; T-CELLS ; EXPRESSION ; SURVIVAL ; LIGAND ; IRRADIATION
英文摘要

Objective: To study the effect of tumor infiltrating lymphocytes at cancer nest on local control of rectal cancer after preoperative radiotherapy. Methods: From Jan. 1999 to Oct. 2007, a total of 107 patients with rectal cancer were reviewed. They were treated by preoperative radiotherapy, 30 Gy/10 fractions/12 days. Two weeks later, the patient underwent a surgical operation. Their pathological samples were kept in our hospital before and after radiotherapy. Lymphocyte infiltration (LI) degree, pathologic degradation and fibrosis degree after radiotherapy in paraffin section were evaluated under microscope. Results: After followed-up of 21 months (2-86 months), a total of 107 patients were reviewed. Univariate analysis showed that lymphocyte infiltration (LI), fibrosis and pathologic changes after radiotherapy were significant factors on local control. Logistic regression analysis showed that LI after radiotherapy was a significant effect factor on local control. Conclusion: LI, fibrosis and pathologic degradation after radiotherapy are significant for local control of rectal cancer after preoperative radiotherapy. LI after radiotherapy was a significantly prognostic index for local control of rectal cancer after preoperative radiotherapy.

语种英语
WOS记录号WOS:000259368400013
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62091
专题北京大学临床肿瘤学院_医学影像科
北京大学临床肿瘤学院_肿瘤放疗科
作者单位Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Radiotherapy, Beijing 100142, Peoples R China
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Xu Gang,Xu Bo,Zhang Shan-wen. Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):222-229.
APA Xu Gang,Xu Bo,&Zhang Shan-wen.(2008).Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy.CHINESE JOURNAL OF CANCER RESEARCH,20(3),222-229.
MLA Xu Gang,et al."Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy".CHINESE JOURNAL OF CANCER RESEARCH 20.3(2008):222-229.
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