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学科主题: 临床医学
题名:
Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy
作者: Xu Gang; Xu Bo; Zhang Shan-wen
关键词: rectal cancer ; tumor infiltrating lymphocyte ; preoperative radiotherapy ; local control ; prognosis ; immunohistochemistry ; downstaging
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2008-09-01
DOI: 10.1007/S11670-008-0222-X
卷: 20, 期:3, 页:222-229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; COLORECTAL-CANCER ; ESOPHAGEAL-CARCINOMA ; PROGNOSTIC FACTORS ; FAS COUNTERATTACK ; T-CELLS ; EXPRESSION ; SURVIVAL ; LIGAND ; IRRADIATION
英文摘要:

Objective: To study the effect of tumor infiltrating lymphocytes at cancer nest on local control of rectal cancer after preoperative radiotherapy. Methods: From Jan. 1999 to Oct. 2007, a total of 107 patients with rectal cancer were reviewed. They were treated by preoperative radiotherapy, 30 Gy/10 fractions/12 days. Two weeks later, the patient underwent a surgical operation. Their pathological samples were kept in our hospital before and after radiotherapy. Lymphocyte infiltration (LI) degree, pathologic degradation and fibrosis degree after radiotherapy in paraffin section were evaluated under microscope. Results: After followed-up of 21 months (2-86 months), a total of 107 patients were reviewed. Univariate analysis showed that lymphocyte infiltration (LI), fibrosis and pathologic changes after radiotherapy were significant factors on local control. Logistic regression analysis showed that LI after radiotherapy was a significant effect factor on local control. Conclusion: LI, fibrosis and pathologic degradation after radiotherapy are significant for local control of rectal cancer after preoperative radiotherapy. LI after radiotherapy was a significantly prognostic index for local control of rectal cancer after preoperative radiotherapy.

语种: 英语
WOS记录号: WOS:000259368400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62091
Appears in Collections:北京大学临床肿瘤学院_医学影像科_期刊论文

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作者单位: Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Radiotherapy, Beijing 100142, Peoples R China

Recommended Citation:
Xu Gang,Xu Bo,Zhang Shan-wen. Effect of tumor infiltrating lymphocyte on local control of rectal cancer after preoperative radiotherapy[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):222-229.
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