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学科主题: 临床医学
题名:
Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer
作者: You, WC; Zhang, L; Pan, KF; Jiang, J; Chang, YS; Perez-Perez, GI; Liu, WD; Ma, JL; Gail, MH; Blaser, MJ; Fraumeni, JF; Xu, GW
关键词: H. pylori ; CagA ; children ; garlic ; gastric cancer
刊名: ANNALS OF EPIDEMIOLOGY
发表日期: 2001-11-01
卷: 11, 期:8, 页:543-546
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: PRECANCEROUS LESIONS ; INFECTION ; ADENOCARCINOMA ; ANTIBODIES ; POPULATION ; AGE
英文摘要:

BACKGROUND: Studies in adult populations in selected countries with widely varying rates of gastric cancer have shown a weak correlation between gastric cancer mortality rates and the prevalence of CagA+ strains of H. pylori. However, only limited data are available in ethnically homogenous populations with varying rates in the same region.

METHODS; We compared the prevalence of H. pylori in general and of CagA+ strains in particular among children in Shandong Province, China in areas at high (Linqu County) and low risk (Cangshan County) of gastric cancer. H. pylori status among children aged 3 to 12 years was determined by C-13-UBT, and CagA status was determined by enzyme-linked immunosorbent assay (ELISA). Because of the difficulty in obtaining blood from young children aged 3 to 4 years and from some children aged 5 years, CagA status was determined among part of children 5 years old and children 6 to 12 years old.

RESULTS; Among 98 children aged 3 to 12 years in Linqu, 68 (69.4%) was H. pylori-positive, as compared with 29 (28.7%) among 101 children in Cangshan. Among children positive for C-13-UBT, the proportion of the CagA+ strains were identified was 46 (88.5%) of 52 in Linqu and 13 (81.3%) of 16 in Cangshan, respectively.

CONCLUSIONS: The prevalence of H. pylori was nearly three times higher among children in Linqu than in Cangshan, which may contribute to the large differential in gastric cancer rates for two neighboring populations in Shandong Province, (C) 2001 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000172092300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62098
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Beijing Inst Canc Res, Beijing, Peoples R China
2.Peking Univ, Sch Oncol, Beijing, Peoples R China
3.Vanderbilt Univ, Ctr Med, Nashville, TN USA
4.Linqu Publ Hlth Bur, Linqu, Peoples R China
5.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
6.Beijing Union Med Coll, Beijing, Peoples R China

Recommended Citation:
You, WC,Zhang, L,Pan, KF,et al. Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer[J]. ANNALS OF EPIDEMIOLOGY,2001,11(8):543-546.
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