IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer
You, WC; Zhang, L; Pan, KF; Jiang, J; Chang, YS; Perez-Perez, GI; Liu, WD; Ma, JL; Gail, MH; Blaser, MJ; Fraumeni, JF; Xu, GW
关键词H. pylori CagA children garlic gastric cancer
刊名ANNALS OF EPIDEMIOLOGY
2001-11-01
11期:8页:543-546
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]PRECANCEROUS LESIONS ; INFECTION ; ADENOCARCINOMA ; ANTIBODIES ; POPULATION ; AGE
英文摘要

BACKGROUND: Studies in adult populations in selected countries with widely varying rates of gastric cancer have shown a weak correlation between gastric cancer mortality rates and the prevalence of CagA+ strains of H. pylori. However, only limited data are available in ethnically homogenous populations with varying rates in the same region.

METHODS; We compared the prevalence of H. pylori in general and of CagA+ strains in particular among children in Shandong Province, China in areas at high (Linqu County) and low risk (Cangshan County) of gastric cancer. H. pylori status among children aged 3 to 12 years was determined by C-13-UBT, and CagA status was determined by enzyme-linked immunosorbent assay (ELISA). Because of the difficulty in obtaining blood from young children aged 3 to 4 years and from some children aged 5 years, CagA status was determined among part of children 5 years old and children 6 to 12 years old.

RESULTS; Among 98 children aged 3 to 12 years in Linqu, 68 (69.4%) was H. pylori-positive, as compared with 29 (28.7%) among 101 children in Cangshan. Among children positive for C-13-UBT, the proportion of the CagA+ strains were identified was 46 (88.5%) of 52 in Linqu and 13 (81.3%) of 16 in Cangshan, respectively.

CONCLUSIONS: The prevalence of H. pylori was nearly three times higher among children in Linqu than in Cangshan, which may contribute to the large differential in gastric cancer rates for two neighboring populations in Shandong Province, (C) 2001 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000172092300004
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62098
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Beijing Inst Canc Res, Beijing, Peoples R China
2.Peking Univ, Sch Oncol, Beijing, Peoples R China
3.Vanderbilt Univ, Ctr Med, Nashville, TN USA
4.Linqu Publ Hlth Bur, Linqu, Peoples R China
5.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
6.Beijing Union Med Coll, Beijing, Peoples R China
推荐引用方式
GB/T 7714
You, WC,Zhang, L,Pan, KF,et al. Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer[J]. ANNALS OF EPIDEMIOLOGY,2001,11(8):543-546.
APA You, WC.,Zhang, L.,Pan, KF.,Jiang, J.,Chang, YS.,...&Xu, GW.(2001).Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer.ANNALS OF EPIDEMIOLOGY,11(8),543-546.
MLA You, WC,et al."Helicobacter pylori prevalence and CagA status among children in two counties of china with high and low risks of gastric cancer".ANNALS OF EPIDEMIOLOGY 11.8(2001):543-546.
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