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学科主题: 口腔医学
题名:
Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma
作者: Qi, Wei1; Guo, Jinsong2; Wu, Shan4; Su, Bo2; Zhang, Lei3; Pan, Jie1; Zhang, Jue2,4
关键词: salivary adenoid cystic carcinoma ; nanosecond pulsed electric field ; pingyangmycin ; extracellular matrix metalloproteinase inducer ; synergism
刊名: ONCOLOGY REPORTS
发表日期: 2014-05-01
DOI: 10.3892/or.2014.3063
卷: 31, 期:5, 页:2220-2228
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; MATRIX METALLOPROTEINASE INDUCER ; RESISTANT CANCER-CELLS ; EXTRACELLULAR-MATRIX ; PHOSPHATIDYLSERINE TRANSLOCATION ; PULMONARY-FIBROSIS ; DISTANT METASTASES ; SELF-DESTRUCT ; TUMOR-GROWTH ; KB CELLS
英文摘要:

Adenoid cystic carcinoma (ACC) is one of the most common malignant neoplasms in salivary glands. To evaluate the therapeutic effects of nanosecond pulsed electric field (nsPEF) combined with pingyangmycin (PYM) on salivary gland adenoid cystic carcinoma (SACC), ACC high metastatic cell line (SACC-LM) and low metastatic cell line (SACC-83) were tested by CCK-8 assay, cell clonogenic assay, flow cytometry and Transwell assay. Extracellular matrix metalloproteinase inducer (EMMPRIN) expression was tested by western blotting to verify the synergistic mechanism of nsPEF and PYM. The results showed that nsPEF inhibited the cell proliferation of both cell lines, and the inhibitory effect was strongly associated with time and electrical field strength. Moreover, PYM combined with nsPEF may enhance the suppression effect significantly, even at a very low dose (0.01 mu g/ml). The synergistic effects may contribute to the downregulation of EMMPRIN expression resulting from the application of nsPEF. For SACC, nsPEF combined with chemotherapy agents may be a valuable strategy not only to improve the treatment effect and prognosis, but also to reduce the side-effects of chemotherapy.

语种: 英语
WOS记录号: WOS:000337947200033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62103
Appears in Collections:北京大学口腔医学院_综合治疗科_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Gen Dent, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Peking Univ, Coll Engn, Beijing 100871, Peoples R China

Recommended Citation:
Qi, Wei,Guo, Jinsong,Wu, Shan,et al. Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma[J]. ONCOLOGY REPORTS,2014,31(5):2220-2228.
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