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学科主题基础医学
hSSB1 regulates both the stability and the transcriptional activity of p53
Xu, Shuangbing1; Wu, Yuanzhong1; Chen, Qiong1; Cao, Jingying1; Hu, Kaishun1; Tang, Jianjun1; Sang, Yi1; Lai, Fenju1; Wang, Li1; Zhang, Ruhua1; Li, Sheng-Ping2; Zeng, Yi-Xin1; Yin, Yuxin3; Kang, Tiebang1
关键词hSSB1 p53 stability transcriptional activity acetylation
刊名CELL RESEARCH
2013-03-01
DOI10.1038/cr.2012.162
23期:3页:423-435
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China
研究领域[WOS]Cell Biology
关键词[WOS]REPLICATION PROTEIN-A ; DOUBLE-STRAND BREAKS ; DNA-BINDING ; POSTTRANSLATIONAL MODIFICATIONS ; MEDIATED DEGRADATION ; GENOMIC STABILITY ; TUMOR SUPPRESSION ; HUMAN CANCERS ; MRN COMPLEX ; DAMAGE
英文摘要

The tumor suppressor p53 is essential for several cellular processes that are involved in the response to diverse genotoxic stress, including cell cycle arrest, DNA repair, apoptosis and senescence. Studies of the regulation of p53 have mostly focused on its stability and transactivation; however, new regulatory molecules for p53 have also been frequently identified. Here, we report that human ssDNA binding protein SSB1 (hSSB1), a novel DNA damage-associated protein, can interact with p53 and protect p53 from ubiquitin-mediated degradation. Furthermore, hSSB1 also associates with the acetyltransferase p300 and is required for efficient transcriptional activation of the p53 target gene p21 by affecting the acetylation of p53 at lysine382. Functionally, the hSSB1 knockdown-induced abrogation of the G2/M checkpoint is partially dependent on p53 or p300. Collectively, our results indicate that hSSB1 may regulate DNA damage checkpoints by positively modulating p53 and its downstream target p21.

语种英语
所属项目编号2010CB912201 ; 2012CB967000 ; 81171890 ; 81125015 ; 30930045
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000316375000014
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62107
专题基础医学院_北京大学系统生物医学研究所
作者单位1.Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, Dept Liver Canc, Guangzhou 510060, Guangdong, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Inst Syst Biomed, Beijing 100191, Peoples R China
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Xu, Shuangbing,Wu, Yuanzhong,Chen, Qiong,et al. hSSB1 regulates both the stability and the transcriptional activity of p53[J]. CELL RESEARCH,2013,23(3):423-435.
APA Xu, Shuangbing.,Wu, Yuanzhong.,Chen, Qiong.,Cao, Jingying.,Hu, Kaishun.,...&Kang, Tiebang.(2013).hSSB1 regulates both the stability and the transcriptional activity of p53.CELL RESEARCH,23(3),423-435.
MLA Xu, Shuangbing,et al."hSSB1 regulates both the stability and the transcriptional activity of p53".CELL RESEARCH 23.3(2013):423-435.
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