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学科主题: 基础医学
题名:
hSSB1 regulates both the stability and the transcriptional activity of p53
作者: Xu, Shuangbing1; Wu, Yuanzhong1; Chen, Qiong1; Cao, Jingying1; Hu, Kaishun1; Tang, Jianjun1; Sang, Yi1; Lai, Fenju1; Wang, Li1; Zhang, Ruhua1; Li, Sheng-Ping2; Zeng, Yi-Xin1; Yin, Yuxin3; Kang, Tiebang1
关键词: hSSB1 ; p53 ; stability ; transcriptional activity ; acetylation
刊名: CELL RESEARCH
发表日期: 2013-03-01
DOI: 10.1038/cr.2012.162
卷: 23, 期:3, 页:423-435
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: REPLICATION PROTEIN-A ; DOUBLE-STRAND BREAKS ; DNA-BINDING ; POSTTRANSLATIONAL MODIFICATIONS ; MEDIATED DEGRADATION ; GENOMIC STABILITY ; TUMOR SUPPRESSION ; HUMAN CANCERS ; MRN COMPLEX ; DAMAGE
英文摘要:

The tumor suppressor p53 is essential for several cellular processes that are involved in the response to diverse genotoxic stress, including cell cycle arrest, DNA repair, apoptosis and senescence. Studies of the regulation of p53 have mostly focused on its stability and transactivation; however, new regulatory molecules for p53 have also been frequently identified. Here, we report that human ssDNA binding protein SSB1 (hSSB1), a novel DNA damage-associated protein, can interact with p53 and protect p53 from ubiquitin-mediated degradation. Furthermore, hSSB1 also associates with the acetyltransferase p300 and is required for efficient transcriptional activation of the p53 target gene p21 by affecting the acetylation of p53 at lysine382. Functionally, the hSSB1 knockdown-induced abrogation of the G2/M checkpoint is partially dependent on p53 or p300. Collectively, our results indicate that hSSB1 may regulate DNA damage checkpoints by positively modulating p53 and its downstream target p21.

语种: 英语
所属项目编号: 2010CB912201 ; 2012CB967000 ; 81171890 ; 81125015 ; 30930045
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000316375000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62107
Appears in Collections:基础医学院_北京大学系统生物医学研究所_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, Dept Liver Canc, Guangzhou 510060, Guangdong, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Inst Syst Biomed, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Shuangbing,Wu, Yuanzhong,Chen, Qiong,et al. hSSB1 regulates both the stability and the transcriptional activity of p53[J]. CELL RESEARCH,2013,23(3):423-435.
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