北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 生物物理学系  > 期刊论文
学科主题: 基础医学
题名:
Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma
作者: Wu, Xiong-Zhi; Xie, Guang-Ru; Chen, Dan
关键词: angiogenesis ; hepatocarcinogenesis ; hepatocellular carcinoma ; hypoxia induced factor-1 ; hypoxia ; metastasis
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2007-08-01
DOI: 10.1111/j.1440-1746.2007.04997.x
卷: 22, 期:8, 页:1178-1182
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; INDUCIBLE FACTOR-I ; FACTOR UP-REGULATION ; HEPATOMA-CELLS ; INDUCED APOPTOSIS ; TUMOR-GROWTH ; HEPG2 CELLS ; ARTERIAL EMBOLIZATION ; VEGF EXPRESSION ; GENE-EXPRESSION
英文摘要:

Hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of hepatocellular carcinoma (HCC); suppresses differentiation and apoptosis of HCC; and consequently leads to resistance of transarterial embolization (with or without chemotherapy). Because transarterial embolization contributes to angiogenesis via inducing hypoxia, therapy combined with transarterial embolization and antiangiogenic therapy provides a new strategy for the treatment of HCC. Unfortunately, hypoxia leads to the escape of HCC cells from transarterial embolization and antiangiogenic therapy. Thus combined therapy that induces and targets hypoxia may be of benefit to HCC patients. Because angiogenesis plays an important role in recurrence of HCC after resection, antiangiogenic therapy is beneficial to HCC patients following surgical resection of the tumor.

语种: 英语
WOS记录号: WOS:000248544200006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62111
Appears in Collections:基础医学院_生物物理学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Hypoxia and hepatocellular carcinoma_ The therapeutic target for hepatocellular .pdf(103KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Tianjin Med Univ, Canc Inst & Hosp, Dept Integrat Oncol, Tianjin 300060, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100871, Peoples R China

Recommended Citation:
Wu, Xiong-Zhi,Xie, Guang-Ru,Chen, Dan. Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2007,22(8):1178-1182.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Xiong-Zhi]'s Articles
[Xie, Guang-Ru]'s Articles
[Chen, Dan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Xiong-Zhi]‘s Articles
[Xie, Guang-Ru]‘s Articles
[Chen, Dan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace