IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma
Wu, Xiong-Zhi; Xie, Guang-Ru; Chen, Dan
关键词angiogenesis hepatocarcinogenesis hepatocellular carcinoma hypoxia induced factor-1 hypoxia metastasis
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2007-08-01
DOI10.1111/j.1440-1746.2007.04997.x
22期:8页:1178-1182
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; INDUCIBLE FACTOR-I ; FACTOR UP-REGULATION ; HEPATOMA-CELLS ; INDUCED APOPTOSIS ; TUMOR-GROWTH ; HEPG2 CELLS ; ARTERIAL EMBOLIZATION ; VEGF EXPRESSION ; GENE-EXPRESSION
英文摘要

Hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of hepatocellular carcinoma (HCC); suppresses differentiation and apoptosis of HCC; and consequently leads to resistance of transarterial embolization (with or without chemotherapy). Because transarterial embolization contributes to angiogenesis via inducing hypoxia, therapy combined with transarterial embolization and antiangiogenic therapy provides a new strategy for the treatment of HCC. Unfortunately, hypoxia leads to the escape of HCC cells from transarterial embolization and antiangiogenic therapy. Thus combined therapy that induces and targets hypoxia may be of benefit to HCC patients. Because angiogenesis plays an important role in recurrence of HCC after resection, antiangiogenic therapy is beneficial to HCC patients following surgical resection of the tumor.

语种英语
WOS记录号WOS:000248544200006
引用统计
被引频次:111[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62111
专题北京大学基础医学院_生物物理学系
作者单位1.Tianjin Med Univ, Canc Inst & Hosp, Dept Integrat Oncol, Tianjin 300060, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100871, Peoples R China
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Wu, Xiong-Zhi,Xie, Guang-Ru,Chen, Dan. Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2007,22(8):1178-1182.
APA Wu, Xiong-Zhi,Xie, Guang-Ru,&Chen, Dan.(2007).Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,22(8),1178-1182.
MLA Wu, Xiong-Zhi,et al."Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 22.8(2007):1178-1182.
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