学科主题临床医学
On the Low Surface Tension of Lung Surfactant
Zhang, Hong1,2; Wang, Yi E.1; Fan, Qihui1; Zuo, Yi Y.1
刊名LANGMUIR
2011-07-05
DOI10.1021/la201482n
27期:13页:8351-8358
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]ATOMIC-FORCE MICROSCOPY ; AIR-WATER-INTERFACE ; PULMONARY SURFACTANT ; SP-B ; INSOLUBLE MONOLAYERS ; LANGMUIR MONOLAYERS ; LIPID MONOLAYERS ; IN-VITRO ; SP-A ; SP-C
英文摘要

Natural lung surfactant contains less than 40% disaturated phospholipids, mainly dipalmitoylphosphatidylcholine (DPPC). The mechanism by which lung surfactant achieves very low near-zero surface tensions, well below its equilibrium value, is not fully understood. To date, the low surface tension of lung surfactant is usually explained by a squeeze-out model which predicts that upon film compression non-DPPC components are gradually excluded from the air water interface into a surface-associated surfactant reservoir. However, detailed experimental evidence of the squeeze-out within the physiologically relevant high surface pressure range is still lacking. In the present work, we studied four animal-derived clinical surfactant preparations, including Survanta, Curosurf, Infasurf, and BLES. By comparing compression isotherms and lateral structures of these surfactant films obtained by atomic force microscopy within the physiologically relevant high surface pressure range, we have derived an updated squeeze-out model. Our model suggests that the squeeze-out originates from fluid phases of a phase-separated monolayer. The squeeze-out process follows a nucleation growth model and only occurs within a narrow surface pressure range around the equilibrium spreading pressure of lung surfactant. After the squeeze-out, three-dimensional nuclei stop growing, thereby resulting in a DPPC-enriched interfacial monolayer to reduce the air water surface tension to very low values.

语种英语
WOS记录号WOS:000292124000049
项目编号44936
资助机构University of Hawaii at Manoa ; Hawaii Community Foundation ; Peking University
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62118
专题北京大学第一临床医学院_呼吸和危重症医学科
作者单位1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA
2.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China
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GB/T 7714
Zhang, Hong,Wang, Yi E.,Fan, Qihui,et al. On the Low Surface Tension of Lung Surfactant[J]. LANGMUIR,2011,27(13):8351-8358.
APA Zhang, Hong,Wang, Yi E.,Fan, Qihui,&Zuo, Yi Y..(2011).On the Low Surface Tension of Lung Surfactant.LANGMUIR,27(13),8351-8358.
MLA Zhang, Hong,et al."On the Low Surface Tension of Lung Surfactant".LANGMUIR 27.13(2011):8351-8358.
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