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学科主题: 临床医学
题名:
On the Low Surface Tension of Lung Surfactant
作者: Zhang, Hong1,2; Wang, Yi E.1; Fan, Qihui1; Zuo, Yi Y.1
刊名: LANGMUIR
发表日期: 2011-07-05
DOI: 10.1021/la201482n
卷: 27, 期:13, 页:8351-8358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: ATOMIC-FORCE MICROSCOPY ; AIR-WATER-INTERFACE ; PULMONARY SURFACTANT ; SP-B ; INSOLUBLE MONOLAYERS ; LANGMUIR MONOLAYERS ; LIPID MONOLAYERS ; IN-VITRO ; SP-A ; SP-C
英文摘要:

Natural lung surfactant contains less than 40% disaturated phospholipids, mainly dipalmitoylphosphatidylcholine (DPPC). The mechanism by which lung surfactant achieves very low near-zero surface tensions, well below its equilibrium value, is not fully understood. To date, the low surface tension of lung surfactant is usually explained by a squeeze-out model which predicts that upon film compression non-DPPC components are gradually excluded from the air water interface into a surface-associated surfactant reservoir. However, detailed experimental evidence of the squeeze-out within the physiologically relevant high surface pressure range is still lacking. In the present work, we studied four animal-derived clinical surfactant preparations, including Survanta, Curosurf, Infasurf, and BLES. By comparing compression isotherms and lateral structures of these surfactant films obtained by atomic force microscopy within the physiologically relevant high surface pressure range, we have derived an updated squeeze-out model. Our model suggests that the squeeze-out originates from fluid phases of a phase-separated monolayer. The squeeze-out process follows a nucleation growth model and only occurs within a narrow surface pressure range around the equilibrium spreading pressure of lung surfactant. After the squeeze-out, three-dimensional nuclei stop growing, thereby resulting in a DPPC-enriched interfacial monolayer to reduce the air water surface tension to very low values.

语种: 英语
所属项目编号: 44936
项目资助者: University of Hawaii at Manoa ; Hawaii Community Foundation ; Peking University
WOS记录号: WOS:000292124000049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62118
Appears in Collections:北京大学第一临床医学院_呼吸和危重症医学科_期刊论文

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作者单位: 1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA
2.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Hong,Wang, Yi E.,Fan, Qihui,et al. On the Low Surface Tension of Lung Surfactant[J]. LANGMUIR,2011,27(13):8351-8358.
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