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学科主题: 临床医学
题名:
Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence
作者: Jiang, Ping1; Liu, Chen2; Wang, Junjie1; Yang, Ruijie1; Jiang, Yuliang1; Tian, Suqing1
关键词: Chest wall tumor metastasis recurrence radiotherapy ; I-125 seed implantation
刊名: TECHNOLOGY IN CANCER RESEARCH & TREATMENT
发表日期: 2015-02-01
DOI: 10.7785/tcrt.2012.500402
卷: 14, 期:1, 页:11-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CANCER ; STEREOTACTIC BODY RADIOTHERAPY ; PANCREATIC-CARCINOMA ; RADIATION-THERAPY ; SALVAGE THERAPY ; BREAST-CANCER ; TUMORS ; BRACHYTHERAPY ; OUTCOMES ; RISK
英文摘要:

To evaluate the efficacy and safety of I-125 seeds implantation for refractory chest wall (CW) metastasis or recurrence under CT guidance. In addition we assessed initial data obtained on the therapeutic response for refractory CW metastasis or recurrence. Twenty consecutive patients underwent permanent implantation of I-125 seeds (from Jul. 2004 to Jan. 2011) under computed tomography (CT) guidance. Postoperative dosimetry was routinely performed for all patients. The actuarial D90 of the implanted I-125 seeds ranged from 100 Gy to 160 Gy (median: 130 Gy). The activity of I-125 seeds ranged from 0.5 mCi to 0.78 mCi (median: 0.71 mCi). The total number of seeds implanted ranged from 8 to 269 (median: 53). The follow-up period ranged from 3 to 54 months (median: 11.5 months). The survival and local control probabilities were calculated by the Kaplan-Meier method. Among all the 20 patients, 3 patients had complete remission CR (15%), 12 patients had partial remission PR (60%), 5 patients had stable disease SD. The 1-, 2-, 3-and 4-year tumor control rates were all 88.7% respectively. The 1- and 2-, 3-, 4-year cancer specific survival rates were 56.5% and 47.1%, 47.1%, 47.1% respectively. The 1- and 2-, 3-, 4-year overall survival rates were 53.3% and 35.6%, 35.6%, 35.6% respectively, with a median survival of 15 months (95% CI, 7.0-22.9). Mild brachial plexus injury was seen in one patient; grade 1 or 2 skin reactions were seen in 6 patients (30%) who had received external beam radiation therapy (EBRT) before. No grade 3 and 4 skin side effects were found. Rib fracture, ulceration, pneumothorax or hemopneumothorax were not seen. Interstitial permanent implantation of I-125 seeds under CT guidance is feasible, efficacious and safe for refractory CW metastasis or recurrence.

语种: 英语
WOS记录号: WOS:000354548000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62124
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol Oncol, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Ping,Liu, Chen,Wang, Junjie,et al. Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence[J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT,2015,14(1):11-18.
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