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学科主题临床医学
Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence
Jiang, Ping1; Liu, Chen2; Wang, Junjie1; Yang, Ruijie1; Jiang, Yuliang1; Tian, Suqing1
关键词Chest wall tumor metastasis recurrence radiotherapy I-125 seed implantation
刊名TECHNOLOGY IN CANCER RESEARCH & TREATMENT
2015-02-01
DOI10.7785/tcrt.2012.500402
14期:1页:11-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CELL LUNG-CANCER ; STEREOTACTIC BODY RADIOTHERAPY ; PANCREATIC-CARCINOMA ; RADIATION-THERAPY ; SALVAGE THERAPY ; BREAST-CANCER ; TUMORS ; BRACHYTHERAPY ; OUTCOMES ; RISK
英文摘要

To evaluate the efficacy and safety of I-125 seeds implantation for refractory chest wall (CW) metastasis or recurrence under CT guidance. In addition we assessed initial data obtained on the therapeutic response for refractory CW metastasis or recurrence. Twenty consecutive patients underwent permanent implantation of I-125 seeds (from Jul. 2004 to Jan. 2011) under computed tomography (CT) guidance. Postoperative dosimetry was routinely performed for all patients. The actuarial D90 of the implanted I-125 seeds ranged from 100 Gy to 160 Gy (median: 130 Gy). The activity of I-125 seeds ranged from 0.5 mCi to 0.78 mCi (median: 0.71 mCi). The total number of seeds implanted ranged from 8 to 269 (median: 53). The follow-up period ranged from 3 to 54 months (median: 11.5 months). The survival and local control probabilities were calculated by the Kaplan-Meier method. Among all the 20 patients, 3 patients had complete remission CR (15%), 12 patients had partial remission PR (60%), 5 patients had stable disease SD. The 1-, 2-, 3-and 4-year tumor control rates were all 88.7% respectively. The 1- and 2-, 3-, 4-year cancer specific survival rates were 56.5% and 47.1%, 47.1%, 47.1% respectively. The 1- and 2-, 3-, 4-year overall survival rates were 53.3% and 35.6%, 35.6%, 35.6% respectively, with a median survival of 15 months (95% CI, 7.0-22.9). Mild brachial plexus injury was seen in one patient; grade 1 or 2 skin reactions were seen in 6 patients (30%) who had received external beam radiation therapy (EBRT) before. No grade 3 and 4 skin side effects were found. Rib fracture, ulceration, pneumothorax or hemopneumothorax were not seen. Interstitial permanent implantation of I-125 seeds under CT guidance is feasible, efficacious and safe for refractory CW metastasis or recurrence.

语种英语
WOS记录号WOS:000354548000002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62124
专题北京大学第三临床医学院_肿瘤放疗科
北京大学第三临床医学院_肿瘤治疗中心
作者单位1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol Oncol, Beijing 100191, Peoples R China
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GB/T 7714
Jiang, Ping,Liu, Chen,Wang, Junjie,et al. Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence[J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT,2015,14(1):11-18.
APA Jiang, Ping,Liu, Chen,Wang, Junjie,Yang, Ruijie,Jiang, Yuliang,&Tian, Suqing.(2015).Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence.TECHNOLOGY IN CANCER RESEARCH & TREATMENT,14(1),11-18.
MLA Jiang, Ping,et al."Computed Tomography (CT)-guided Interstitial Permanent Implantation of I-125 Seeds for Refractory Chest Wall Metastasis or Recurrence".TECHNOLOGY IN CANCER RESEARCH & TREATMENT 14.1(2015):11-18.
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