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Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration
Guo, Chunmei1,2; Yang, Yang1,2; Su, Yun′ ai1,2; Si, Tianmei1,2
刊名JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
2010
DOI10.1155/2010/783297
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]NEUROTROPHIC FACTOR ; MESSENGER-RNA ; BRAIN ; PHENCYCLIDINE
英文摘要

Neonatal blockade of N-methyl-D-aspartic acid (NMDA) receptors represents one of experimental animal models for schizophrenia. This study is to investigate the long-term brain-derived neurotrophic factor (BDNF) expression profiles in different regions and correlation with "schizophrenia-like" behaviors in the adolescence and adult of this rat model. The NMDA receptor antagonist MK801 was administered to female Sprague-Dawley rats on postnatal days (PND) 5 through 14. Open-field test was performed on PND 42, and PND 77 to examine the validity of the current model. BDNF protein levels in hippocampus and prefrontal cortex (PFC) were analyzed on PND 15, PND 42, and PND 77. Results showed that neonatal challenge with MK-801 persistently elevated locomotor activity as well as BDNF expression; the alterations in BDNF expression varied at different developing stages and among brain regions. However, these findings provide neurochemical evidence that the blockade of NMDA receptors during brain development results in long-lasting alterations in BDNF expression and might contribute to neurobehavioral pathology of the present animal model for schizophrenia. Further study in the mechanisms and roles of the BDNF may lead to better understanding of the pathophysiology of schizophrenia.

语种英语
WOS记录号WOS:000280883600001
项目编号30770775 ; 30800361
资助机构National Natural Scientific Foundation of China
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62127
专题北京大学精神卫生研究所
北京大学精神卫生研究所_药理室
北京大学精神卫生研究所_医务处
作者单位1.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Dept Psychopharmacol, Beijing 100191, Peoples R China
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GB/T 7714
Guo, Chunmei,Yang, Yang,Su, Yun&prime,et al. Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2010.
APA Guo, Chunmei,Yang, Yang,Su, Yun&prime,ai,&Si, Tianmei.(2010).Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration.JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY.
MLA Guo, Chunmei,et al."Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration".JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010).
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