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学科主题: 精神卫生
题名:
Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration
作者: Guo, Chunmei1,2; Yang, Yang1,2; Su, Yun′ ai1,2; Si, Tianmei1,2
刊名: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
发表日期: 2010
DOI: 10.1155/2010/783297
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: NEUROTROPHIC FACTOR ; MESSENGER-RNA ; BRAIN ; PHENCYCLIDINE
英文摘要:

Neonatal blockade of N-methyl-D-aspartic acid (NMDA) receptors represents one of experimental animal models for schizophrenia. This study is to investigate the long-term brain-derived neurotrophic factor (BDNF) expression profiles in different regions and correlation with "schizophrenia-like" behaviors in the adolescence and adult of this rat model. The NMDA receptor antagonist MK801 was administered to female Sprague-Dawley rats on postnatal days (PND) 5 through 14. Open-field test was performed on PND 42, and PND 77 to examine the validity of the current model. BDNF protein levels in hippocampus and prefrontal cortex (PFC) were analyzed on PND 15, PND 42, and PND 77. Results showed that neonatal challenge with MK-801 persistently elevated locomotor activity as well as BDNF expression; the alterations in BDNF expression varied at different developing stages and among brain regions. However, these findings provide neurochemical evidence that the blockade of NMDA receptors during brain development results in long-lasting alterations in BDNF expression and might contribute to neurobehavioral pathology of the present animal model for schizophrenia. Further study in the mechanisms and roles of the BDNF may lead to better understanding of the pathophysiology of schizophrenia.

语种: 英语
所属项目编号: 30770775 ; 30800361
项目资助者: National Natural Scientific Foundation of China
WOS记录号: WOS:000280883600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62127
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Dept Psychopharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Chunmei,Yang, Yang,Su, Yun&prime,et al. Postnatal BDNF Expression Profiles in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by MK-801 Administration[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2010.
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