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学科主题: 药物依赖
题名:
Basolateral Amygdala Cdk5 Activity Mediates Consolidation and Reconsolidation of Memories for Cocaine Cues
作者: Li, Fang-qiong1,2,3; Xue, Yan-xue3; Wang, Ji-shi1,2; Fang, Qin1,2; Li, Yan-qin3; Zhu, Wei-Li3; He, Ying-ying1,2; Liu, Jian-feng3; Xue, Li-fen3; Shaham, Yavin4; Lu, Lin3
刊名: JOURNAL OF NEUROSCIENCE
发表日期: 2010-08-04
DOI: 10.1523/JNEUROSCI.2112-10.2010
卷: 30, 期:31, 页:10351-10359
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CYCLIN-DEPENDENT KINASE-5 ; CONDITIONED PLACE PREFERENCE ; DRUG-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS ; REINFORCING EFFICACY ; SIGNALING PATHWAY ; CONTEXTUAL FEAR ; NMDA RECEPTORS ; REWARD ; INCUBATION
英文摘要:

Cocaine use and relapse involves learned associations between cocaine-associated environmental contexts and discrete stimuli and cocaine effects. Initially, these contextual and discrete cues undergo memory consolidation after being paired with cocaine exposure. During abstinence, cocaine cue memories can undergo memory reconsolidation after cue exposure without the drug. We used a conditioned place preference (CPP) procedure in rats to study the role of neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) in consolidation and reconsolidation of cocaine cue memories. We found that the expression of cocaine CPP in drug-free tests 1 d after CPP training (four pairings of 10 mg/kg cocaine with one context and four pairings of saline with a different context) increased Cdk5 activity, and levels of the Cdk5 activator p35 in basolateral but not central amygdala. We also found that basolateral (but not central) amygdala injections of the Cdk5 inhibitor beta-butyrolactone (100 ng/side) immediately (but not 6 h) after cocaine-context pairings during training prevented subsequent cocaine CPP expression. After training, acute basolateral (but not central) amygdala beta-butyrolactone injections immediately before testing prevented the expression of cocaine CPP; this effect was also observed on a second test performed 1 d later, suggesting an effect on reconsolidation of cocaine cue memories. In support, basolateral beta-butyrolactone injections, given immediately (but not 6 h) after a single exposure to the cocaine-paired context, prevented cocaine CPP expression 1 and 14 d after the injections. Results indicate that basolateral amygdala Cdk5 activity is critical for consolidation and reconsolidation of the memories of cocaine-associated environmental cues.

语种: 英语
所属项目编号: 2007CB512302 ; 09G0762 ; 7092058 ; 2008-59
项目资助者: National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of Guizhou Province
WOS记录号: WOS:000280789600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62134
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Natl Inst Drug Abuse, Behav Neurosci Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Li, Fang-qiong,Xue, Yan-xue,Wang, Ji-shi,et al. Basolateral Amygdala Cdk5 Activity Mediates Consolidation and Reconsolidation of Memories for Cocaine Cues[J]. JOURNAL OF NEUROSCIENCE,2010,30(31):10351-10359.
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