IR@PKUHSC  > 北京大学药学院
学科主题药学
Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension
Wang, Yancai1,2; Liu, Zhaoping1; Zhang, Dianrui2; Gao, Xihui1; Zhang, Xiaoyu1; Duan, Cunxian2; Jia, Lejiao2; Feng, Feifei2; Huang, Yaojian3; Shen, Yuemao2; Zhang, Qiang4
关键词Deacety mycoepoxydiene Nanosuspension Dissolution velocity Delivery system Cancer therapy
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2011-04-01
DOI10.1016/j.colsurfb.2010.10.029
83期:2页:189-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]POORLY SOLUBLE DRUGS ; DISSOLUTION RATE ENHANCEMENT ; HIGH-PRESSURE HOMOGENIZATION ; PHARMACOKINETIC EVALUATION ; NANOCRYSTALS ; DELIVERY ; FORMULATION ; NANOPARTICLES ; SUSPENSIONS ; TECHNOLOGY
英文摘要

Deacety mycoepoxydiene (DM), extracted from Phomopsis sp. A123 of thalassiomycetes, is a novel and potent anti-cancer agent. Due to its physicochemical characteristics, the drug, a poorly water-soluble weak acid, shows poor solubility and dissolution characteristics. To improve the solubility and dissolution, formulation of DM as nanosuspension has been performed in this study. Nanosuspensions were developed by high-pressure homogenization (HPH) (DissoCubes (R) Technology) and transformed into dry powder by freeze-drying. The nanosuspension produced was then investigated using optical microscope, photon correlation spectroscopy (PCS), zeta potential measurement, SEM, TEM, AFM, DSC and XRD. To verify the theoretical hypothesis on the benefit of increased surface area, in vitro saturation solubility and dissolution profile were investigated. In addition, the in vitro cell cytotoxicity was examined. Results showed that a narrow size distributed nanosuspension composed of unchanged crystalline state with a mean particle size of 515 +/- 18 nm, a polydispersity index of 0.12 +/- 0.03 and a zeta potential of -23.1 +/- 3.5 mV was obtained. In the in vitro dissolution test an accelerated dissolution velocity and increased saturation solubility could be shown for the MD nanosuspension. The in vitro cytotoxicity experiments provided evidence for an enhanced efficacy of the DM nanosuspension formulation compared to free DM solution. Taken together, these results illustrate the opportunity to formulate DM in nanosuspension form as an anti-prostate cancer delivery system. (C) 2010 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000287268000001
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62136
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Jinan 250012, Peoples R China
2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
3.Shandong Univ, Ctr New Drug Evaluat, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yancai,Liu, Zhaoping,Zhang, Dianrui,et al. Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,83(2):189-197.
APA Wang, Yancai.,Liu, Zhaoping.,Zhang, Dianrui.,Gao, Xihui.,Zhang, Xiaoyu.,...&Zhang, Qiang.(2011).Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension.COLLOIDS AND SURFACES B-BIOINTERFACES,83(2),189-197.
MLA Wang, Yancai,et al."Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension".COLLOIDS AND SURFACES B-BIOINTERFACES 83.2(2011):189-197.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yancai]的文章
[Liu, Zhaoping]的文章
[Zhang, Dianrui]的文章
百度学术
百度学术中相似的文章
[Wang, Yancai]的文章
[Liu, Zhaoping]的文章
[Zhang, Dianrui]的文章
必应学术
必应学术中相似的文章
[Wang, Yancai]的文章
[Liu, Zhaoping]的文章
[Zhang, Dianrui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。