北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension
作者: Wang, Yancai1,2; Liu, Zhaoping1; Zhang, Dianrui2; Gao, Xihui1; Zhang, Xiaoyu1; Duan, Cunxian2; Jia, Lejiao2; Feng, Feifei2; Huang, Yaojian3; Shen, Yuemao2; Zhang, Qiang4
关键词: Deacety mycoepoxydiene ; Nanosuspension ; Dissolution velocity ; Delivery system ; Cancer therapy
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2011-04-01
DOI: 10.1016/j.colsurfb.2010.10.029
卷: 83, 期:2, 页:189-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]: Biophysics ; Chemistry ; Materials Science
关键词[WOS]: POORLY SOLUBLE DRUGS ; DISSOLUTION RATE ENHANCEMENT ; HIGH-PRESSURE HOMOGENIZATION ; PHARMACOKINETIC EVALUATION ; NANOCRYSTALS ; DELIVERY ; FORMULATION ; NANOPARTICLES ; SUSPENSIONS ; TECHNOLOGY
英文摘要:

Deacety mycoepoxydiene (DM), extracted from Phomopsis sp. A123 of thalassiomycetes, is a novel and potent anti-cancer agent. Due to its physicochemical characteristics, the drug, a poorly water-soluble weak acid, shows poor solubility and dissolution characteristics. To improve the solubility and dissolution, formulation of DM as nanosuspension has been performed in this study. Nanosuspensions were developed by high-pressure homogenization (HPH) (DissoCubes (R) Technology) and transformed into dry powder by freeze-drying. The nanosuspension produced was then investigated using optical microscope, photon correlation spectroscopy (PCS), zeta potential measurement, SEM, TEM, AFM, DSC and XRD. To verify the theoretical hypothesis on the benefit of increased surface area, in vitro saturation solubility and dissolution profile were investigated. In addition, the in vitro cell cytotoxicity was examined. Results showed that a narrow size distributed nanosuspension composed of unchanged crystalline state with a mean particle size of 515 +/- 18 nm, a polydispersity index of 0.12 +/- 0.03 and a zeta potential of -23.1 +/- 3.5 mV was obtained. In the in vitro dissolution test an accelerated dissolution velocity and increased saturation solubility could be shown for the MD nanosuspension. The in vitro cytotoxicity experiments provided evidence for an enhanced efficacy of the DM nanosuspension formulation compared to free DM solution. Taken together, these results illustrate the opportunity to formulate DM in nanosuspension form as an anti-prostate cancer delivery system. (C) 2010 Published by Elsevier B.V.

语种: 英语
所属项目编号: 2009CB930300 ; 2009ZX09502-001
项目资助者: National Basic Research Program of China (973 Program) ; Major scientific and technological specialized project for Significant New Formulation of New Drugs
WOS记录号: WOS:000287268000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62136
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Shandong Univ, Coll Pharm, Jinan 250012, Peoples R China
2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
3.Shandong Univ, Ctr New Drug Evaluat, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yancai,Liu, Zhaoping,Zhang, Dianrui,et al. Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,83(2):189-197.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Yancai]'s Articles
[Liu, Zhaoping]'s Articles
[Zhang, Dianrui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Yancai]‘s Articles
[Liu, Zhaoping]‘s Articles
[Zhang, Dianrui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace