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学科主题: 临床医学
题名:
Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization
作者: Wang, B.1; Xu, H.; Gao, Z. Q.; Ning, H. F.; Sun, Y. Q.; Cao, G. W.
关键词: angiogenesis ; endothelial growth factors ; hepatocellular carcinoma ; microvessel density ; therapeutic chemoembolization
刊名: ACTA RADIOLOGICA
发表日期: 2008
DOI: 10.1080/02841850801958890
卷: 49, 期:5, 页:523-529
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: LIPIODOL CHEMOEMBOLIZATION ; BCL-2 OVEREXPRESSION ; BREAST-CARCINOMA ; LIVER METASTASIS ; IN-VIVO ; ANGIOGENESIS ; SORAFENIB ; HYPOXIA ; TNP-470 ; RESECTION
英文摘要:

Background: Changes in the biological behavior of residual viable hepatocellular carcinoma (HCC) tissue after transcatheter arterial chemoembolization (TACE) remain unclear. Several studies have reported that TACE inhibits tumor angiogenesis and induces tumor cell apoptosis, while other studies have found that TACE stimulates tumor angiogenesis and thus increases the proliferative activity of the tumor cells to some degree.

Purpose: To investigate the intratumoral microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in residual surviving cancerous tissue after TACE in HCC.

Material and Methods: Tumor specimens from 63 histopathologically diagnosed patients were studied: 42 comprising the control group (treated by surgery alone) and 21 comprising the TACE group (those treated by TACE 1-2 times prior to surgical resection). The number of VEGF-positive cells, MVD, and microvessel diameter were measured.

Results: The MVD was 51.69 +/- 18.17 and 58.57 +/- 15.75 in the control and TACE groups, respectively. There was no significant difference between the two groups (t = 1.48, P > 0.05). The microvessel diameter was 17.62 +/- 10.54 mm and 15.79 +/- 7.65 mm in the control and TACE groups, respectively, indicating no significant difference between the two groups (t = 0.71, P > 0.05). The number of VEGF-positive cells in the TACE group, i.e., 243.66 +/- 88.88, was higher than that in the control group, i.e., 138.26 +/- 65.24 (t = 5.34, P<0.01). TACE increased VEGF expression in the residual surviving HCC tissues, and there was a positive correlation between VEGF expression and MVD (r = 0.4936, t = 4.4329, P<0.05) in the HCC tissue.

Conclusion: The study indicates that the residual surviving cancerous tissue in HCC after TACE has a rich vascularity. TACE increases VEGF expression in the residual surviving cancerous tissue.

语种: 英语
WOS记录号: WOS:000256978100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62138
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Weifang Med Univ, Dept Med Biol, Weifang 261042, Peoples R China
2.Weifang Med Univ, Med Imaging Ctr Affiliated Hosp, Dept Radiol, Weifang 261042, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, B.,Xu, H.,Gao, Z. Q.,et al. Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization[J]. ACTA RADIOLOGICA,2008,49(5):523-529.
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