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学科主题: 基础医学
题名:
HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway
作者: Liu, Ning3; Xing, Rui1,2; Yang, Chengzhi1,2; Tian, Aiju1,2; Lv, Zhizhen1,2; Sun, Ningning3; Gao, Xiang3; Zhang, Youyi1,2; Li, Zijian1,2
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2014
DOI: 10.1039/c3mb70525k
卷: 10, 期:7, 页:1932-1939
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: HUMAN CARDIAC FIBROBLASTS ; ACTIN-BINDING PROTEIN-1 ; GROWTH-FACTOR RECEPTOR ; BETA(2)-ADRENERGIC RECEPTOR ; ACTIVATION ; HYPERTROPHY ; INHIBITION ; HIP-55 ; EXTRACELLULAR-SIGNAL-REGULATED-KINASE-1/2 ; TRANSACTIVATION
英文摘要:

The activation of beta-adrenergic receptors (beta-ARs) plays a key role in regulating cardiac function. However, the detailed regulatory mechanisms of beta-AR-induced fibrosis are still unclear. We used a proteomics approach to analyze the changes in protein expression patterns in cardiac fibrosis with beta-AR stimulation. HIP-55 (also called debrin-like; DBNL) was revealed as a novel regulator in the signaling regulatory network with beta-AR activation. Further studies of both HIP-55-overexpressed and -deficient cardiac fibroblasts indicated that HIP-55 negatively regulated beta-AR-activated cardiac fibroblast proliferation and the proliferative signaling pathway may be associated with the extracellular signal-regulated protein kinase (ERK) activation. Our data provide a new mechanistic insight into the role of HIP-55 in beta-AR-induced cardiac fibroblast proliferation and suggest a new treatment strategy for proliferative disorders.

语种: 英语
所属项目编号: 2011CB503903 ; 81070078 ; 81270157 ; 21175055 ; 7102158 ; 20110739 ; 2012210
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Jilin Province Science and Technology Department ; Jilin University Bethune Project B
WOS记录号: WOS:000337103600030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62145
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Jilin Univ, Hosp 2, Cent Lab, Changchun 130041, Peoples R China
2.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Key Lab Mol Cardiovasc Sci, Hosp 3,Minist Educ,Inst Vasc Med,Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Ning,Xing, Rui,Yang, Chengzhi,et al. HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway[J]. MOLECULAR BIOSYSTEMS,2014,10(7):1932-1939.
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