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学科主题基础医学
HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway
Liu, Ning3; Xing, Rui1,2; Yang, Chengzhi1,2; Tian, Aiju1,2; Lv, Zhizhen1,2; Sun, Ningning3; Gao, Xiang3; Zhang, Youyi1,2; Li, Zijian1,2
刊名MOLECULAR BIOSYSTEMS
2014
DOI10.1039/c3mb70525k
10期:7页:1932-1939
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]HUMAN CARDIAC FIBROBLASTS ; ACTIN-BINDING PROTEIN-1 ; GROWTH-FACTOR RECEPTOR ; BETA(2)-ADRENERGIC RECEPTOR ; ACTIVATION ; HYPERTROPHY ; INHIBITION ; HIP-55 ; EXTRACELLULAR-SIGNAL-REGULATED-KINASE-1/2 ; TRANSACTIVATION
英文摘要

The activation of beta-adrenergic receptors (beta-ARs) plays a key role in regulating cardiac function. However, the detailed regulatory mechanisms of beta-AR-induced fibrosis are still unclear. We used a proteomics approach to analyze the changes in protein expression patterns in cardiac fibrosis with beta-AR stimulation. HIP-55 (also called debrin-like; DBNL) was revealed as a novel regulator in the signaling regulatory network with beta-AR activation. Further studies of both HIP-55-overexpressed and -deficient cardiac fibroblasts indicated that HIP-55 negatively regulated beta-AR-activated cardiac fibroblast proliferation and the proliferative signaling pathway may be associated with the extracellular signal-regulated protein kinase (ERK) activation. Our data provide a new mechanistic insight into the role of HIP-55 in beta-AR-induced cardiac fibroblast proliferation and suggest a new treatment strategy for proliferative disorders.

语种英语
WOS记录号WOS:000337103600030
项目编号2011CB503903 ; 81070078 ; 81270157 ; 21175055 ; 7102158 ; 20110739 ; 2012210
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Jilin Province Science and Technology Department ; Jilin University Bethune Project B
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62145
专题北京大学基础医学院_心血管所
北京大学第三临床医学院_心血管内科
作者单位1.Jilin Univ, Hosp 2, Cent Lab, Changchun 130041, Peoples R China
2.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Key Lab Mol Cardiovasc Sci, Hosp 3,Minist Educ,Inst Vasc Med,Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Ning,Xing, Rui,Yang, Chengzhi,et al. HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway[J]. MOLECULAR BIOSYSTEMS,2014,10(7):1932-1939.
APA Liu, Ning.,Xing, Rui.,Yang, Chengzhi.,Tian, Aiju.,Lv, Zhizhen.,...&Li, Zijian.(2014).HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway.MOLECULAR BIOSYSTEMS,10(7),1932-1939.
MLA Liu, Ning,et al."HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway".MOLECULAR BIOSYSTEMS 10.7(2014):1932-1939.
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