IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection
Liu, Meiqiang; Cao, Bangwei; Zhang, Hongkun; Dai, Yue; Liu, Xiaolin; Xu, Changqing
关键词hepatitis B virus IFN-gamma haplotype
刊名IMMUNOGENETICS
2006-11-01
DOI10.1007/s00251-006-0161-y
58期:11页:859-864
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Immunology
研究领域[WOS]Genetics & Heredity ; Immunology
关键词[WOS]IFN-GAMMA ; INTERLEUKIN-10 GENES ; POLYMORPHISMS ; TUBERCULOSIS ; DISEASES ; REGIONS
英文摘要

In general, cytokines encoded by different genes of human genome might strongly influence host cell-mediated immune responses, which play an important role in the clearance of virus by the infected host. Interferon gamma (IFN-gamma) produced by T lymphocytes and natural killer cells plays an essential role in affecting cellular immune responses. A functional study demonstrated that two single nucleotide polymorphisms located in the IFN-gamma gene intron (at positions +874 and +2109) were involved in its transcriptional regulation. The aim of this study was to evaluate whether IFN-gamma gene polymorphisms or its haplotypes might be associated with predisposition to hepatitis B virus (HBV) infection in the Chinese population. The study included 181 cases with HBV infection and 272 gender, age-matched healthy controls. All genotyping were identified by polymerase chain reaction in association with the measurement of amplification refractory mutation system. A significant difference was observed between case and control groups. The frequency of +874A allele was significantly higher in patients than in controls (OR = 2.25, 95% CI = 1.69-2.99, P < 0.0001). However, no significant difference was found in the allelic frequencies of IFN-gamma +2109A/G between cases and controls (P > 0.05). By haplotype analysis, the frequency of haplotype AG (+874A and +2109G) revealed a significant difference in the cases in comparison to controls (P < 0.0001). Multiple logistic regression analysis showed that individuals possessing haplotype AG had an increased likelihood of HBV infection (OR = 8.14, 95% CI = 4.98-13.30). Our results suggest that haplotype AG containing +874A and +2109G may be a crucial risk factor of genetic susceptibility to HBV infection in the Chinese population.

语种英语
WOS记录号WOS:000242295500001
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62157
专题北京大学第一临床医学院_临床药理研究所
作者单位1.Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China
2.Shandong Univ, Coll Med, Jinan 250014, Shandong, Peoples R China
3.Peking Univ, First Hosp, Inst Clin Pharmacol, Dept Antiinfect, Beijing, Peoples R China
4.Peking Univ, First Hosp, Dept Blood Transfus, Beijing, Peoples R China
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GB/T 7714
Liu, Meiqiang,Cao, Bangwei,Zhang, Hongkun,et al. Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection[J]. IMMUNOGENETICS,2006,58(11):859-864.
APA Liu, Meiqiang,Cao, Bangwei,Zhang, Hongkun,Dai, Yue,Liu, Xiaolin,&Xu, Changqing.(2006).Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection.IMMUNOGENETICS,58(11),859-864.
MLA Liu, Meiqiang,et al."Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection".IMMUNOGENETICS 58.11(2006):859-864.
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