北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所  > 期刊论文
学科主题: 临床医学
题名:
Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection
作者: Liu, Meiqiang; Cao, Bangwei; Zhang, Hongkun; Dai, Yue; Liu, Xiaolin; Xu, Changqing
关键词: hepatitis B virus ; IFN-gamma ; haplotype
刊名: IMMUNOGENETICS
发表日期: 2006-11-01
DOI: 10.1007/s00251-006-0161-y
卷: 58, 期:11, 页:859-864
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Immunology
研究领域[WOS]: Genetics & Heredity ; Immunology
关键词[WOS]: IFN-GAMMA ; INTERLEUKIN-10 GENES ; POLYMORPHISMS ; TUBERCULOSIS ; DISEASES ; REGIONS
英文摘要:

In general, cytokines encoded by different genes of human genome might strongly influence host cell-mediated immune responses, which play an important role in the clearance of virus by the infected host. Interferon gamma (IFN-gamma) produced by T lymphocytes and natural killer cells plays an essential role in affecting cellular immune responses. A functional study demonstrated that two single nucleotide polymorphisms located in the IFN-gamma gene intron (at positions +874 and +2109) were involved in its transcriptional regulation. The aim of this study was to evaluate whether IFN-gamma gene polymorphisms or its haplotypes might be associated with predisposition to hepatitis B virus (HBV) infection in the Chinese population. The study included 181 cases with HBV infection and 272 gender, age-matched healthy controls. All genotyping were identified by polymerase chain reaction in association with the measurement of amplification refractory mutation system. A significant difference was observed between case and control groups. The frequency of +874A allele was significantly higher in patients than in controls (OR = 2.25, 95% CI = 1.69-2.99, P < 0.0001). However, no significant difference was found in the allelic frequencies of IFN-gamma +2109A/G between cases and controls (P > 0.05). By haplotype analysis, the frequency of haplotype AG (+874A and +2109G) revealed a significant difference in the cases in comparison to controls (P < 0.0001). Multiple logistic regression analysis showed that individuals possessing haplotype AG had an increased likelihood of HBV infection (OR = 8.14, 95% CI = 4.98-13.30). Our results suggest that haplotype AG containing +874A and +2109G may be a crucial risk factor of genetic susceptibility to HBV infection in the Chinese population.

语种: 英语
WOS记录号: WOS:000242295500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62157
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China
2.Shandong Univ, Coll Med, Jinan 250014, Shandong, Peoples R China
3.Peking Univ, First Hosp, Inst Clin Pharmacol, Dept Antiinfect, Beijing, Peoples R China
4.Peking Univ, First Hosp, Dept Blood Transfus, Beijing, Peoples R China

Recommended Citation:
Liu, Meiqiang,Cao, Bangwei,Zhang, Hongkun,et al. Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection[J]. IMMUNOGENETICS,2006,58(11):859-864.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Meiqiang]'s Articles
[Cao, Bangwei]'s Articles
[Zhang, Hongkun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Meiqiang]‘s Articles
[Cao, Bangwei]‘s Articles
[Zhang, Hongkun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace