IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children
Deng, Wenjun1; Liu, Yanling2; Liu, Angie Dong3; Holmberg, Lukas3; Ochs, Todd4; Li, Xueying5; Yang, Jinyan1; Tang, Chaoshu6,7; Du, Junbao1; Jin, Hongfang1
关键词Postural orthostatic tachycardia syndrome Midodrine hydrochloride Predictor Receiver operating characteristic curve
刊名PEDIATRIC CARDIOLOGY
2014-04-01
DOI10.1007/s00246-013-0843-9
35期:4页:719-725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pediatrics
研究领域[WOS]Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]THERAPEUTIC RESPONSE ; VASOVAGAL SYNCOPE ; HYDROCHLORIDE ; INTOLERANCE ; MANAGEMENT ; PREDICTOR
英文摘要

Postural orthostatic tachycardia syndrome (POTS) is common, and has a serious impact on children′s quality of life. Midodrine hydrochloride, an alpha 1-adrenoreceptor agonist, is an effective treatment. The study was designed to examine the therapeutic efficacy of midodrine hydrochloride by quantifying changes in blood pressure during the head-up test (HUT), in children with POTS. Overall, 104 out of 110 children with POTS were treated with midodrine hydrochloride and successfully followed-up. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes were analyzed during the HUT. In a retrospective analysis, a receiver operating characteristic (ROC) curve was used to analyze the therapeutic predictive value of pre-treatment changes in SBP, DBP, and a combination of both, from the supine position to standing, in the subjects. The increase of SBP and DBP from the supine position to standing in responders were significantly lower than that of the non-responders. The ROC curve showed that midodrine hydrochloride for children with POTS would be predicted to be effective when the pre-treatment increase of SBP was a parts per thousand currency sign0 mmHg, or when the pre-treatment increase of DBP was a parts per thousand currency sign6.5 mmHg (from the supine position to standing), yielding a sensitivity of 72 % and specificity of 88 %. The area under the curve was 0.744 and 0.809, respectively. Hence, the results suggested that looking at the changes in blood pressure during the HUT was useful in predicting the response to midodrine hydrochloride in children with POTS.

语种英语
WOS记录号WOS:000333165400023
项目编号2012CB517806 ; 2012BAI03B03
资助机构Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62159
专题北京大学第一临床医学院_儿科
作者单位1.Chaling Ctr Dis Control & Prevent, Zhuzhou 412400, Peoples R China
2.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
3.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
4.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
5.Ann & Robert Lurie Childrens Hosp, Feinberg Sch Med, Chicago, IL 60611 USA
6.Peking Univ, Dept Med Stat, Hosp 1, Beijing 100034, Peoples R China
7.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Deng, Wenjun,Liu, Yanling,Liu, Angie Dong,et al. Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children[J]. PEDIATRIC CARDIOLOGY,2014,35(4):719-725.
APA Deng, Wenjun.,Liu, Yanling.,Liu, Angie Dong.,Holmberg, Lukas.,Ochs, Todd.,...&Jin, Hongfang.(2014).Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children.PEDIATRIC CARDIOLOGY,35(4),719-725.
MLA Deng, Wenjun,et al."Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children".PEDIATRIC CARDIOLOGY 35.4(2014):719-725.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Deng, Wenjun]的文章
[Liu, Yanling]的文章
[Liu, Angie Dong]的文章
百度学术
百度学术中相似的文章
[Deng, Wenjun]的文章
[Liu, Yanling]的文章
[Liu, Angie Dong]的文章
必应学术
必应学术中相似的文章
[Deng, Wenjun]的文章
[Liu, Yanling]的文章
[Liu, Angie Dong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。