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学科主题: 临床医学
题名:
Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children
作者: Deng, Wenjun1; Liu, Yanling2; Liu, Angie Dong3; Holmberg, Lukas3; Ochs, Todd4; Li, Xueying5; Yang, Jinyan1; Tang, Chaoshu6,7; Du, Junbao1; Jin, Hongfang1
关键词: Postural orthostatic tachycardia syndrome ; Midodrine hydrochloride ; Predictor ; Receiver operating characteristic curve
刊名: PEDIATRIC CARDIOLOGY
发表日期: 2014-04-01
DOI: 10.1007/s00246-013-0843-9
卷: 35, 期:4, 页:719-725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pediatrics
研究领域[WOS]: Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]: THERAPEUTIC RESPONSE ; VASOVAGAL SYNCOPE ; HYDROCHLORIDE ; INTOLERANCE ; MANAGEMENT ; PREDICTOR
英文摘要:

Postural orthostatic tachycardia syndrome (POTS) is common, and has a serious impact on children′s quality of life. Midodrine hydrochloride, an alpha 1-adrenoreceptor agonist, is an effective treatment. The study was designed to examine the therapeutic efficacy of midodrine hydrochloride by quantifying changes in blood pressure during the head-up test (HUT), in children with POTS. Overall, 104 out of 110 children with POTS were treated with midodrine hydrochloride and successfully followed-up. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes were analyzed during the HUT. In a retrospective analysis, a receiver operating characteristic (ROC) curve was used to analyze the therapeutic predictive value of pre-treatment changes in SBP, DBP, and a combination of both, from the supine position to standing, in the subjects. The increase of SBP and DBP from the supine position to standing in responders were significantly lower than that of the non-responders. The ROC curve showed that midodrine hydrochloride for children with POTS would be predicted to be effective when the pre-treatment increase of SBP was a parts per thousand currency sign0 mmHg, or when the pre-treatment increase of DBP was a parts per thousand currency sign6.5 mmHg (from the supine position to standing), yielding a sensitivity of 72 % and specificity of 88 %. The area under the curve was 0.744 and 0.809, respectively. Hence, the results suggested that looking at the changes in blood pressure during the HUT was useful in predicting the response to midodrine hydrochloride in children with POTS.

语种: 英语
所属项目编号: 2012CB517806 ; 2012BAI03B03
项目资助者: Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support
WOS记录号: WOS:000333165400023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62159
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Chaling Ctr Dis Control & Prevent, Zhuzhou 412400, Peoples R China
2.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
3.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
4.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
5.Ann & Robert Lurie Childrens Hosp, Feinberg Sch Med, Chicago, IL 60611 USA
6.Peking Univ, Dept Med Stat, Hosp 1, Beijing 100034, Peoples R China
7.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Deng, Wenjun,Liu, Yanling,Liu, Angie Dong,et al. Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children[J]. PEDIATRIC CARDIOLOGY,2014,35(4):719-725.
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