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学科主题临床医学
Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children
Deng, Wenjun1; Liu, Yanling2; Liu, Angie Dong3; Holmberg, Lukas3; Ochs, Todd4; Li, Xueying5; Yang, Jinyan1; Tang, Chaoshu6,7; Du, Junbao1; Jin, Hongfang1
关键词Postural orthostatic tachycardia syndrome Midodrine hydrochloride Predictor Receiver operating characteristic curve
刊名PEDIATRIC CARDIOLOGY
2014-04-01
DOI10.1007/s00246-013-0843-9
35期:4页:719-725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pediatrics
资助者Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support
研究领域[WOS]Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]THERAPEUTIC RESPONSE ; VASOVAGAL SYNCOPE ; HYDROCHLORIDE ; INTOLERANCE ; MANAGEMENT ; PREDICTOR
英文摘要

Postural orthostatic tachycardia syndrome (POTS) is common, and has a serious impact on children′s quality of life. Midodrine hydrochloride, an alpha 1-adrenoreceptor agonist, is an effective treatment. The study was designed to examine the therapeutic efficacy of midodrine hydrochloride by quantifying changes in blood pressure during the head-up test (HUT), in children with POTS. Overall, 104 out of 110 children with POTS were treated with midodrine hydrochloride and successfully followed-up. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes were analyzed during the HUT. In a retrospective analysis, a receiver operating characteristic (ROC) curve was used to analyze the therapeutic predictive value of pre-treatment changes in SBP, DBP, and a combination of both, from the supine position to standing, in the subjects. The increase of SBP and DBP from the supine position to standing in responders were significantly lower than that of the non-responders. The ROC curve showed that midodrine hydrochloride for children with POTS would be predicted to be effective when the pre-treatment increase of SBP was a parts per thousand currency sign0 mmHg, or when the pre-treatment increase of DBP was a parts per thousand currency sign6.5 mmHg (from the supine position to standing), yielding a sensitivity of 72 % and specificity of 88 %. The area under the curve was 0.744 and 0.809, respectively. Hence, the results suggested that looking at the changes in blood pressure during the HUT was useful in predicting the response to midodrine hydrochloride in children with POTS.

语种英语
所属项目编号2012CB517806 ; 2012BAI03B03
资助者Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support
WOS记录号WOS:000333165400023
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62159
Collection北京大学第一临床医学院_儿科
作者单位1.Chaling Ctr Dis Control & Prevent, Zhuzhou 412400, Peoples R China
2.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
3.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
4.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
5.Ann & Robert Lurie Childrens Hosp, Feinberg Sch Med, Chicago, IL 60611 USA
6.Peking Univ, Dept Med Stat, Hosp 1, Beijing 100034, Peoples R China
7.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Deng, Wenjun,Liu, Yanling,Liu, Angie Dong,et al. Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children[J]. PEDIATRIC CARDIOLOGY,2014,35(4):719-725.
APA Deng, Wenjun.,Liu, Yanling.,Liu, Angie Dong.,Holmberg, Lukas.,Ochs, Todd.,...&Jin, Hongfang.(2014).Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children.PEDIATRIC CARDIOLOGY,35(4),719-725.
MLA Deng, Wenjun,et al."Difference between Supine and Upright Blood Pressure Associates to the Efficacy of Midodrine on Postural Orthostatic Tachycardia Syndrome (POTS) in Children".PEDIATRIC CARDIOLOGY 35.4(2014):719-725.
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