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学科主题: 临床医学
题名:
Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia
作者: Yang, R.; Xia, T.; Xu, G.; Li, Z.; Ying, Z.; Xu, X.
刊名: TRANSPLANTATION PROCEEDINGS
发表日期: 2008-12-01
DOI: 10.1016/j.transproceed.2008.03.176
卷: 40, 期:10, 页:3500-3504
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Surgery ; Transplantation
研究领域[WOS]: Immunology ; Surgery ; Transplantation
关键词[WOS]: IMMUNOSUPPRESSED PATIENTS ; CELLS ; RESPONSES ; FREQUENCY
英文摘要:

Our study sought to investigate the immune response of cytotoxic T lymphocytes to human cytomegalovirus (HCMV) in kidney transplant recipients with virus reactivation. Nine kidney transplant recipients with serum HCMV immunoglobulin G and HLA-A*0201 genotype displayed HCMV pp65 antigenemia and were compared with 29 control recipients who were free of antigenemia. The frequency of total HCMV-specific cytotoxic T cells was determined using HLA-A2-NLVPMVATV-pentamer staining. The frequency of HCMV specific interferon (INF)-gamma secreting CD8(+) T cells was determined using intracellular INF-gamma staining after NLVPMVATV pulsing in vitro. The proportion of IFN--y secreting pentamer-stained CD8(+) T cells was calculated, representing the capacity for INF-gamma secretion among HCMV-specific CD8(+) T cells. We observed that the frequency of HCMV-specific pentamer-stained CD8(+) T cells and HCMV-specific IFN--y secreting CD8(+) T cells both remained unchanged, yet the proportion of IFN--y secreting CD8(+) T cells showed a significant difference between the 2 groups (39.2% +/- 17.2% vs 20.0% +/- 13.3% respectively; P =.004), reflecting impaired IFN--y secreting capacity of HCMV-specific CD8(+) T cells among kidney transplant recipients displaying antigenemia, which may be a crucial reason for HCMV reactivation in immunosuppressed patients.

语种: 英语
WOS记录号: WOS:000262133300052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62170
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Yang, R.,Xia, T.,Xu, G.,et al. Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia[J]. TRANSPLANTATION PROCEEDINGS,2008,40(10):3500-3504.
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