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Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia
Yang, R.; Xia, T.; Xu, G.; Li, Z.; Ying, Z.; Xu, X.
刊名TRANSPLANTATION PROCEEDINGS
2008-12-01
DOI10.1016/j.transproceed.2008.03.176
40期:10页:3500-3504
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Surgery ; Transplantation
研究领域[WOS]Immunology ; Surgery ; Transplantation
关键词[WOS]IMMUNOSUPPRESSED PATIENTS ; CELLS ; RESPONSES ; FREQUENCY
英文摘要

Our study sought to investigate the immune response of cytotoxic T lymphocytes to human cytomegalovirus (HCMV) in kidney transplant recipients with virus reactivation. Nine kidney transplant recipients with serum HCMV immunoglobulin G and HLA-A*0201 genotype displayed HCMV pp65 antigenemia and were compared with 29 control recipients who were free of antigenemia. The frequency of total HCMV-specific cytotoxic T cells was determined using HLA-A2-NLVPMVATV-pentamer staining. The frequency of HCMV specific interferon (INF)-gamma secreting CD8(+) T cells was determined using intracellular INF-gamma staining after NLVPMVATV pulsing in vitro. The proportion of IFN--y secreting pentamer-stained CD8(+) T cells was calculated, representing the capacity for INF-gamma secretion among HCMV-specific CD8(+) T cells. We observed that the frequency of HCMV-specific pentamer-stained CD8(+) T cells and HCMV-specific IFN--y secreting CD8(+) T cells both remained unchanged, yet the proportion of IFN--y secreting CD8(+) T cells showed a significant difference between the 2 groups (39.2% +/- 17.2% vs 20.0% +/- 13.3% respectively; P =.004), reflecting impaired IFN--y secreting capacity of HCMV-specific CD8(+) T cells among kidney transplant recipients displaying antigenemia, which may be a crucial reason for HCMV reactivation in immunosuppressed patients.

语种英语
WOS记录号WOS:000262133300052
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62170
专题北京大学第一临床医学院
作者单位Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Yang, R.,Xia, T.,Xu, G.,et al. Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia[J]. TRANSPLANTATION PROCEEDINGS,2008,40(10):3500-3504.
APA Yang, R.,Xia, T.,Xu, G.,Li, Z.,Ying, Z.,&Xu, X..(2008).Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia.TRANSPLANTATION PROCEEDINGS,40(10),3500-3504.
MLA Yang, R.,et al."Human Cytomegalovirus Specific CD8(+) T Lymphocytes Display Interferon-gamma Secretion Impairment in Kidney Transplant Recipients With pp65 Antigenemia".TRANSPLANTATION PROCEEDINGS 40.10(2008):3500-3504.
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