|Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension|
corticotropin releasing factor
atrial natriuretic peptide
|WOS标题词||Science & Technology
|类目[WOS]||Endocrinology & Metabolism
|研究领域[WOS]||Endocrinology & Metabolism
; Neurosciences & Neurology
; CENTRAL AMYGDALOID NUCLEUS
; CARDIOVASCULAR CONTROL MECHANISMS
; RAT SUBFORNICAL ORGAN
; SODIUM-CHLORIDE DIET
; WISTAR-KYOTO RATS
; LONG-TERM CONTROL
It is generally accepted that the essential hypertension (EH) is caused by interactions among congenital gene, multiple pathogenetic pressor factors, and disorder of physiologic depressor factors. The central nervous system may play a key role in the development of EH. The underlying mechanisms, however, are not well understood. Studies show that peptidergic transmitters in the limbic forebrain are involved in long-term regulation of arterial pressure and in the pathogenesis of EH In the limbic forebrain there are peptidergic pressor and depressor circuits. The former includes corticotropin releasing factor-, substance P-, and angiotensin II-circuits; and the latter includes beta-endorphin- and atrial natriuretic peptide-circuits. These circuits extensively interconnect and interact with each other. The altered functions of them may be the pathogenesis of EH. In this review, we focus on the roles of limbic peptidergic circuits in regulation of arterial pressure, relevant to the neurogenetic mechanisms in developing EH. (c) 2006 Elsevier Ltd. All rights reserved.
|作者单位||Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China|
Ku, Y-H.. Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension[J]. NEUROPEPTIDES,2006,40(5):299-308.
Ku, Y-H..(2006).Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension.NEUROPEPTIDES,40(5),299-308.
Ku, Y-H.."Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension".NEUROPEPTIDES 40.5(2006):299-308.
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