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学科主题: 基础医学
题名:
Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension
作者: Ku, Y-H.
关键词: limbic system ; emotion ; stress ; essential hypertension ; corticotropin releasing factor ; substance P ; angiotensin II ; beta-endorphin ; atrial natriuretic peptide
刊名: NEUROPEPTIDES
发表日期: 2006-10-01
DOI: 10.1016/j.npep.2006.05.001
卷: 40, 期:5, 页:299-308
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Neurosciences
研究领域[WOS]: Endocrinology & Metabolism ; Neurosciences & Neurology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; CORTICOTROPIN-RELEASING-FACTOR ; ATRIAL-NATRIURETIC-PEPTIDE ; NUCLEUS-TRACTUS-SOLITARIUS ; CENTRAL AMYGDALOID NUCLEUS ; CARDIOVASCULAR CONTROL MECHANISMS ; RAT SUBFORNICAL ORGAN ; SODIUM-CHLORIDE DIET ; WISTAR-KYOTO RATS ; LONG-TERM CONTROL
英文摘要:

It is generally accepted that the essential hypertension (EH) is caused by interactions among congenital gene, multiple pathogenetic pressor factors, and disorder of physiologic depressor factors. The central nervous system may play a key role in the development of EH. The underlying mechanisms, however, are not well understood. Studies show that peptidergic transmitters in the limbic forebrain are involved in long-term regulation of arterial pressure and in the pathogenesis of EH In the limbic forebrain there are peptidergic pressor and depressor circuits. The former includes corticotropin releasing factor-, substance P-, and angiotensin II-circuits; and the latter includes beta-endorphin- and atrial natriuretic peptide-circuits. These circuits extensively interconnect and interact with each other. The altered functions of them may be the pathogenesis of EH. In this review, we focus on the roles of limbic peptidergic circuits in regulation of arterial pressure, relevant to the neurogenetic mechanisms in developing EH. (c) 2006 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000242297700001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62172
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Ku, Y-H.. Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension[J]. NEUROPEPTIDES,2006,40(5):299-308.
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