学科主题基础医学
Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension
Ku, Y-H.
关键词limbic system emotion stress essential hypertension corticotropin releasing factor substance P angiotensin II beta-endorphin atrial natriuretic peptide
刊名NEUROPEPTIDES
2006-10-01
DOI10.1016/j.npep.2006.05.001
40期:5页:299-308
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Neurosciences
研究领域[WOS]Endocrinology & Metabolism ; Neurosciences & Neurology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; CORTICOTROPIN-RELEASING-FACTOR ; ATRIAL-NATRIURETIC-PEPTIDE ; NUCLEUS-TRACTUS-SOLITARIUS ; CENTRAL AMYGDALOID NUCLEUS ; CARDIOVASCULAR CONTROL MECHANISMS ; RAT SUBFORNICAL ORGAN ; SODIUM-CHLORIDE DIET ; WISTAR-KYOTO RATS ; LONG-TERM CONTROL
英文摘要

It is generally accepted that the essential hypertension (EH) is caused by interactions among congenital gene, multiple pathogenetic pressor factors, and disorder of physiologic depressor factors. The central nervous system may play a key role in the development of EH. The underlying mechanisms, however, are not well understood. Studies show that peptidergic transmitters in the limbic forebrain are involved in long-term regulation of arterial pressure and in the pathogenesis of EH In the limbic forebrain there are peptidergic pressor and depressor circuits. The former includes corticotropin releasing factor-, substance P-, and angiotensin II-circuits; and the latter includes beta-endorphin- and atrial natriuretic peptide-circuits. These circuits extensively interconnect and interact with each other. The altered functions of them may be the pathogenesis of EH. In this review, we focus on the roles of limbic peptidergic circuits in regulation of arterial pressure, relevant to the neurogenetic mechanisms in developing EH. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000242297700001
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62172
专题北京大学基础医学院_生理学与病理生理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
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Ku, Y-H.. Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension[J]. NEUROPEPTIDES,2006,40(5):299-308.
APA Ku, Y-H..(2006).Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension.NEUROPEPTIDES,40(5),299-308.
MLA Ku, Y-H.."Role of limbic peptidergic circuits in regulation of arterial pressure, relevant to development of essential hypertension".NEUROPEPTIDES 40.5(2006):299-308.
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