|Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan|
|Okubo, Yoichiro1; Nemoto, Tetsuo1; Wakayama, Megumi1; Tochigi, Naobumi1; Shinozaki, Minoru1; Ishiwatari, Takao1; Aki, Kyoko1; Tsuchiya, Masaru2; Aoyama, Hajime3; Katsura, Kanade4; Fujii, Takeshi5,6; Nishigami, Takashi; Yokose, Tomoyuki7; Ohkura, Yasuo8; Shibuya, Kazutoshi1,9|
|关键词||Gangliocytic paraganglioma Neuroendocrine tumor Progesterone receptor Pancreatic polypeptide|
|WOS标题词||Science & Technology|
|关键词[WOS]||OF-THE-LITERATURE ; RARE CASE-REPORT ; NEUROENDOCRINE TUMORS ; METASTASES ; DUODENUM|
Background: Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity. To differentiate GP from NET G1 with ease, we conducted a multi-institutional retrospective study analyzing the morphometric and immunohistochemical features of this tumor.
Methods: Since only a limited number of patients with GP could be identified in our institute, we conducted a multi-institutional retrospective study of GP in Japan, which was approved by the Ethics Committee of our medical institute. The obtained tissue sections underwent detailed morphometric and immunohistochemical analyses. Additionally, to differentiate GP from NET G1 with ease, immunohistochemical findings were compared.
Results: In our examination of 12 cases of duodenal GP, we found that epithelioid cells of GP exhibited positive reactivity for progesterone receptor and pancreatic polypeptide, whereas tumor cells of NET G1 were completely negative reactivity for both. Additionally, although GP is considered to be an extremely rare NET, we found that four (40.0%) of the ten patients at our institute with duodenal NET G1 actually had GP.
Conclusions: Although GP is regarded as a rare NET, our results suggest that it accounts for a substantial percentage of duodenal NETs. Additionally, confirmation of immunoreactivity for progesterone receptor and pancreatic polypeptide can assist in differentiating GP from NET G1.
|项目编号||H25-Shinkou-Ippan-006 ; H26-shinkou-Jitsuyouka-Ippan-010 ; 24790364 ; 26860250 ; 26460460 ; 26860774 ; 23-19 ; 23-21 ; 23-28 ; 24-11 ; 24-16 ; 24-27 ; 24-28 ; 25-33|
|资助机构||Health Science Research Grants for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds ; Strategic Research Foundation ; KAKENHI from the Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University project grants ; Yokohama Foundation ; Toho University Medical School ; Kurozumi Medical Foundation|
|作者单位||1.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan|
2.Univ Ryukyus, Dept Pathol & Oncol, Okinawa 9030214, Japan
3.Toranomon Gen Hosp, Dept Pathol, Minato Ku, Tokyo 1058470, Japan
4.Steel Mem Hirohata Hosp, Dept Pathol, Himeji, Hyogo 6711122, Japan
5.Kyorin Univ, Sch Med, Dept Pathol, Mitaka, Tokyo 1818611, Japan
6.Toho Univ, Sch Med, Dept Surg Omori, Div Gen & Gastroenterol Surg,Ota Ku, Tokyo 1438541, Japan
7.Japanese Red Cross Kyoto Daini Hosp, Dept Pathol, Jokyo Ku, Kyoto 6028026, Japan
8.Kanagawa Canc Ctr, Dept Pathol, Asahi Ku, Yokohama, Kanagawa 2450815, Japan
9.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
|Okubo, Yoichiro,Nemoto, Tetsuo,Wakayama, Megumi,et al. Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan[J]. BMC CANCER,2015,15.|
|APA||Okubo, Yoichiro.,Nemoto, Tetsuo.,Wakayama, Megumi.,Tochigi, Naobumi.,Shinozaki, Minoru.,...&Shibuya, Kazutoshi.(2015).Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan.BMC CANCER,15.|
|MLA||Okubo, Yoichiro,et al."Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan".BMC CANCER 15(2015).|