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学科主题: 药学
题名:
Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester
作者: Dong, JC; Wang, X; Li, RT; Zhang, HM; Cheng, TM; Li, CL
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2003-12-15
DOI: 10.1016/j.bmcl.2003.09.047
卷: 13, 期:24, 页:4327-4329
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: NICOTINIC ACETYLCHOLINE-RECEPTORS ; UNIQUE SPIROCYCLOPIPERAZINIUM SALT ; POISON FROG ; ANALOGS ; (+/-)-EPIBATIDINE ; AGONIST ; BINDING ; LIGAND ; BRAIN
英文摘要:

Hydrochloride derivatives 5a-c and quaternary ammonium derivatives 6a-c of epibatidine incorporated with amino acid ester were synthesized and evaluated for their in vivo analgesic activity and toxicity. Among all tested compounds, compound 6c has the most potent analgesic activity. The quaternary ammonium salts 6a and 6c showed better analgesic activity than the corresponding hydrochlorides 5a and 5c. Both 5a-c and 6a-c showed significantly lower toxicity than epibatidine itself. (C) 2003 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000187010700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62181
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Dong, JC,Wang, X,Li, RT,et al. Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(24):4327-4329.
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