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Disease Association and Arthritogenic Potential of Circulating Antibodies against the alpha 1,4-Polygalacturonic Acid Moiety
Dai, Hui1; Dong, Hong-Liang2; Gong, Fang-Yuan2; Sun, Shu-Liang2; Liu, Xiang-Yuan3; Li, Zhan-Guo4; Xiong, Si-Dong2; Gao, Xiao-Ming2
刊名JOURNAL OF IMMUNOLOGY
2014-05-15
DOI10.4049/jimmunol.1303351
192期:10页:4533-4540
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Key Basic Research Programs ; Program for Changjiang Scholars and Innovative Research Team in University ; Natural Science Foundation of China ; Doctoral Program of Higher Education ; National Key Basic Research Programs ; Program for Changjiang Scholars and Innovative Research Team in University ; Natural Science Foundation of China ; Doctoral Program of Higher Education
研究领域[WOS]Immunology
关键词[WOS]SACCHAROMYCES-CEREVISIAE MANNAN ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; RHEUMATOID-ARTHRITIS ; ELEVATED LEVELS ; II COLLAGEN ; CITRULLINATED PROTEINS ; AUTOIMMUNE-DISEASE ; SERUM ANTIBODIES ; MODEL ; IGA
英文摘要

Much progress has been made in recent years on the diagnostic value, Ag specificity, and pathogenic roles of autoantibodies correlated to the development of rheumatoid arthritis (RA) in humans. However, carbohydrate Ag-specific autoantibodies that may also play important roles in RA have largely been ignored. In this article, we report that serum levels of Abs capable of recognizing a1,4-polygalacturonic acid [(PGA); major structural component of pectin] strongly correlate with RA in humans. The measurements of PGA-specific Abs (PGA-Abs) in sera are comparable to rheumatoid factors and anti-cyclic citrullinated peptide Abs as serological diagnostic markers for RA in terms of sensitivity and specificity. Immunohistochemical staining results indicate that the PGA-Abs selectively bound synovial membrane cells and chondrocytes in the joints of both humans and rabbits (but not rodents). Induction of PGA-Abs by s. c. immunization of rabbits with carrier protein-conjugated synthetic PGA led to severe inflammatory reactions (synovial hyperplasia, small vessel proliferation, and inflammatory cell infiltration) in the joints. Injection of affinity purified anti-PGA IgG into the synovial cavity of rabbits resulted in accumulation of proinflammatory cytokines such as TNF-alpha, IL-8, and IL-1 beta in synovial fluid, as well as local pathological damage. We conclude that the PGA-cross-reactive moiety represents a major autoantigen in the joints and can be targeted by autoantibodies capable of triggering arthritogenic responses in vivo.

语种英语
所属项目编号2010CB529102 ; IRT1075 ; 31370908 ; 31070781 ; 81102253 ; 20100001120042
资助者National Key Basic Research Programs ; Program for Changjiang Scholars and Innovative Research Team in University ; Natural Science Foundation of China ; Doctoral Program of Higher Education ; National Key Basic Research Programs ; Program for Changjiang Scholars and Innovative Research Team in University ; Natural Science Foundation of China ; Doctoral Program of Higher Education
WOS记录号WOS:000335973600010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62184
专题基础医学院_免疫学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Soochow Univ, Inst Biol & Med Sci, Sch Biol & Basic Med Sci, Suzhou 215123, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Rheumatol, Affiliated Hosp 3, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Dept Rheumatol, Beijing 100044, Peoples R China
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GB/T 7714
Dai, Hui,Dong, Hong-Liang,Gong, Fang-Yuan,et al. Disease Association and Arthritogenic Potential of Circulating Antibodies against the alpha 1,4-Polygalacturonic Acid Moiety[J]. JOURNAL OF IMMUNOLOGY,2014,192(10):4533-4540.
APA Dai, Hui.,Dong, Hong-Liang.,Gong, Fang-Yuan.,Sun, Shu-Liang.,Liu, Xiang-Yuan.,...&Gao, Xiao-Ming.(2014).Disease Association and Arthritogenic Potential of Circulating Antibodies against the alpha 1,4-Polygalacturonic Acid Moiety.JOURNAL OF IMMUNOLOGY,192(10),4533-4540.
MLA Dai, Hui,et al."Disease Association and Arthritogenic Potential of Circulating Antibodies against the alpha 1,4-Polygalacturonic Acid Moiety".JOURNAL OF IMMUNOLOGY 192.10(2014):4533-4540.
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