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学科主题临床医学
The expression of Toll-like receptors 2, 4 and 9 in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
Wang, H.1,2,3,4; Gou, S. -J.1,5; Zhao, M. -H.1; Chen, M.1
关键词ANCA Toll-like receptor vasculitis
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2014-09-01
DOI10.1111/cei.12365
177期:3页:603-610
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ANCA-ASSOCIATED VASCULITIS ; WEGENERS-GRANULOMATOSIS ; CHINESE PATIENTS ; RENAL HISTOLOGY ; GLOMERULONEPHRITIS ; AUTOANTIBODIES ; DISEASE ; COTRIMOXAZOLE ; RECOGNITION ; ACTIVATION
英文摘要

Increasing evidence suggested that Toll-like receptors (TLRs) were critically involved in immune responses of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to investigate the expression of TLR-2, TLR-4 and TLR-9 in kidneys of patients with ANCA-associated vasculitis. Renal biopsy specimens were collected from 24 patients with AAV. The expression of TLR-2, TLR-4 and TLR-9 in kidneys was detected by immunohistochemistry. Double immunofluorescence staining was performed to detect the expression of TLRs on various kinds of cells. In renal specimens, immunohistochemical examination revealed that expression of TLR-2 and TLR-4 could be detected in the glomeruli of AAV patients, while TLR-2 and TLR-4 were scarcely detected in the glomeruli of normal controls. Double immunofluorescence staining of TLR-2, TLR-4 and CD31 indicated that TLR-4 and TLR-2 were expressed on endothelial cells in the glomeruli. In the tubulointerstitial compartment, expression of TLR-2, TLR-4 and TLR-9 could be detected in both AAV patients and normal controls. The mean optical density of TLR-2 and TLR-4 in the tubulointerstitial compartment in AAV patients were significantly higher than that in normal controls. Among AAV patients, correlation analysis showed that the mean optical density of TLR-4 in the glomeruli correlated inversely with the initial serum creatinine, the proportion of total crescents and the proportion of cellular crescents in renal specimens (r = -0.419, P = 0.041; r = -0.506, P = 0.012; r = -0.505, P = 0.012, respectively). The expression of TLR-2 and TLR-4 was dysregulated in kidneys of AAV patients. The expression of TLR-4 in glomeruli was associated with the severity of renal injury.

语种英语
WOS记录号WOS:000340044000005
项目编号2012CB517700 ; 81370829 ; 81321064 ; 2011BAI10B04
资助机构Chinese 973 project ; National Natural Science Fund ; &prime ; National Key Technology Research and Development (R&amp ; D) Program&prime ; of the Ministry of Science and Technology of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62187
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Tianjin, Peoples R China
3.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100034, Peoples R China
5.Sichuan Univ, Div Renal, Dept Med, West China Hosp, Chengdu 610064, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Wang, H.,Gou, S. -J.,Zhao, M. -H.,et al. The expression of Toll-like receptors 2, 4 and 9 in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2014,177(3):603-610.
APA Wang, H.,Gou, S. -J.,Zhao, M. -H.,&Chen, M..(2014).The expression of Toll-like receptors 2, 4 and 9 in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,177(3),603-610.
MLA Wang, H.,et al."The expression of Toll-like receptors 2, 4 and 9 in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 177.3(2014):603-610.
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