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学科主题: 临床医学
题名:
Assessment of the hypoxic-ischemic encephalopathy in neonates using non-invasive near-infrared spectroscopy
作者: Huang, L; Ding, H; Hou, XL; Zhou, CL; Wang, GZ; Tian, FH
关键词: near-infrared spectroscopy ; cerebral oxygenation ; infant ; inhaling oxygen stimulation
刊名: PHYSIOLOGICAL MEASUREMENT
发表日期: 2004-06-01
DOI: 10.1088/0967-3334/25/3/014
卷: 25, 期:3, 页:749-761
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Engineering, Biomedical ; Physiology
研究领域[WOS]: Biophysics ; Engineering ; Physiology
关键词[WOS]: CEREBRAL BLOOD-FLOW ; OXYGEN-SATURATION ; NEWBORN-INFANTS ; TISSUE OXYGENATION ; VENOUS OCCLUSION ; CARDIAC-SURGERY ; PRETERM INFANTS ; TERM NEWBORN ; NIRO 300 ; OXIMETRY
英文摘要:

This paper introduces a method of monitoring cerebral oxygenation for healthy neonates and neonates with hypoxic-ischemic encephalopathy (HIE) using near-infrared spectroscopy. The object of this study was to investigate whether or not there were differences between the HIE group and the healthy group in terms of NIRS parameters. The subjects were all term neonates, their age ranging from 2 to 18 days. The healthy group included 25 subjects while the HIE group consisted of 16 patients. A prototype NIRS instrument, which provides the data of tissue oxygenation including regional oxygen saturation (602), the increment of oxyhemoglobin concentration and hemoglobin (DeltaHbO(2) and DeltaHb) was used, and the data of rSO(2) was compared with the data from the blood gas analyzer. The result shows that: (1) the mean +/- SD of rSO(2), for the healthy group was 62 +/- 4% in the frontal region under the quiet sleep condition, but the mean +/- SD of rSO(2) for the HIE group was 53 3%. (2) As all subjects inhaled pure oxygen in 21 min(-1) for a period of 60 s, rSO(2) for the healthy group increased rapidly, with the increase in rSO(2) (DeltarSO(2)) being 7 +/- 2.3%, but the increase in rSO(2) for the HIE neonates was 3 +/-1.5%. After inhaling oxygen, DeltaHbO(2) and DeltaHb between the two groups were also significantly different. (3) During all the experiments SpO(2) was monitored, the value of SpO(2) was not significantly different between the two groups. The above observations suggest that the rSO(2) in quiet condition and the values of change of rSO(2), HbO(2), and Hb during the inhalation of oxygen may be used as the parameters to discover and assess the HIE infants.

语种: 英语
WOS记录号: WOS:000222377900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62188
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Peking Univ, Teaching Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Huang, L,Ding, H,Hou, XL,et al. Assessment of the hypoxic-ischemic encephalopathy in neonates using non-invasive near-infrared spectroscopy[J]. PHYSIOLOGICAL MEASUREMENT,2004,25(3):749-761.
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